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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ghlissi, Zohra Hakim, Ahmed Sila, Assaad Mnif, Hela Zeghal, Khaled Rebai, Tarek Bougatef, Ali Sahnoun, Zouheir |
| Description | Author Affiliation: Ghlissi Z ( Research unit of pharmacology and toxicology of xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Tunisia. Electronic address: ghlissi_zohra@yahoo.fr.); Hakim A ( Research unit of pharmacology and toxicology of xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Tunisia.); Sila A ( Unit of enzyme and Bioconversion, National School of Engineering, University of Sfax, Tunisia.); Mnif H ( Anatomopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, Tunisia.); Zeghal K ( Research unit of pharmacology and toxicology of xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Tunisia.); Rebai T ( Laboratory of Histology and Embryology, Faculty of Medicine, University of Sfax, Tunisia.); Bougatef A ( Unit of enzyme and Bioconversion, National School of Engineering, University of Sfax, Tunisia.); Sahnoun Z ( Research unit of pharmacology and toxicology of xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Tunisia.) |
| Abstract | OBJECTIVE: We evaluated the effect of astaxanthin (ASX) and vitamin E (vit E) on colistin methanesulfonate (CMS) induced-nephrotoxicity in rats. METHODS: Animals were treated with sterile saline, 300000 or 450 000 IU/kg/day of CMS, CMS + ASX (20 mg/kg), CMS + vit E (100 mg/kg), or CMS + 1 ml/kg olive oil (OO) for 7 days. The plasma/urine creatinine (Cr) level, urine γ-glutamyl-transferase (GGT) level, and renal tissue activities in malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reductase (GSH), as well as renal histology were performed. RESULTS: CMS induced a tubular damage, increased the GGT and MDA levels, and decreased the activities of SOD, CAT, GPx and GSH. Co-treatment with ASX or vit E restored all biochemical parameters cited above and improved the histopathological damage. CONCLUSION: Nephrotoxicity induced by CMS might be due to oxidative damage. The improvement by ASX or vit E seems to be related to their antioxidant properties. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 37 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antioxidants Pharmacology Kidney Diseases Prevention & Control Vitamin E Animals Anti-bacterial Agents Catalase Metabolism Colistin Creatinine Blood Glutathione Peroxidase Glutathione Reductase Kidney Drug Effects Pathology Chemically Induced Male Malondialdehyde Rats, Wistar Superoxide Dismutase Xanthophylls Gamma-glutamyltransferase Urine Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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