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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ji, Chenglong Zhao, Jianmin Wu, Huifeng |
| Description | Author Affiliation: Ji C ( Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS)); Zhao J ( Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS)); Wu H ( Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS)) |
| Abstract | Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 µg/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 µg/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 37 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Flame Retardants Toxicity Gonads Drug Effects Halogenated Diphenyl Ethers Mytilus Water Pollutants, Chemical Animals Female Metabolism Male Metabolomics Sex Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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