NDLI: Protective effect of curcumin against cytomegalovirus infection in Balb/c mice.

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Protective effect of curcumin against cytomegalovirus infection in Balb/c mice.

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Protective effect of curcumin against cytomegalovirus infection in Balb/c mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lv, Yali Lei, Ning Wang, Dan An, Zhuoling Li, Guangrun Han, Feifei Liu, He Liu, Lihong
Description	Author Affiliation: Lv Y ( Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China.); Lei N ( General Hospital of the Second Artillery, Beijing 100088, PR China.); Wang D ( General Hospital of the Second Artillery, Beijing 100088, PR China.); An Z ( Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China.); Li G ( Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China.); Han F ( Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China.); Liu H ( Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China.); Liu L ( Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China. Electronic address: lvyali_happy@163.com.)
Abstract	Curcumin has been found to suppress the activity of human cytomegalovirus (HCMV) in vitro, whereas its protective effects against HCMV infection in vivo remain unclear. In this study, we aimed to investigate the protective effects of curcumin against HCMV infection in Balb/c mice. Mice were randomly divided into the control, model, model+ganciclovir (positive control), and model+high-dose, model+middle-dose, and model+low-dose curcumin groups. In the model groups, each mouse was given HCMV by tail injection intravenously. Positive control animals were given ganciclovir. Animals in the curcumin treatment groups were given different concentrations of curcumin. The anti-HCMV activities of ganciclovir and curcumin were assessed by serological examination and pathology. Ganciclovir and curcumin treatment reduced the HCMV IgM level and HCMV DNA load; decreased the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), and lactate dehydrogenase (LDH) as well as tumor necrosis factor- (TNF- ) and interleukin-6 (IL-6) generation in infected mice. These treatments also suppressed malondialdehyde (MDA) content and upregulated superoxide dismutase (SOD) and glutathione (GSH) levels. In addition, both treatments prevented pathological changes of the lung, kidney, liver, and heart tissues in infected mice. Our findings indicate that curcumin protected Balb/c mice against HCMV infection possibly by its anti-inflammatory and antioxidant effects.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	37
Journal	Environmental Toxicology and Pharmacology
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2014-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Anti-inflammatory Agents Therapeutic Use Antioxidants Curcumin Cytomegalovirus Infections Drug Therapy Alanine Transaminase Blood Animals Pharmacology Aspartate Aminotransferases Cell Line Creatine Kinase Cytomegalovirus Genetics Immunology Pathology Virology Dna, Viral Analysis Female Glutathione Heart Drug Effects Humans Immunoglobulin M Interleukin-6 Kidney L-lactate Dehydrogenase Liver Lung Male Malondialdehyde Mice, Inbred Balb C Myocardium Spleen Superoxide Dismutase Tumor Necrosis Factor-alpha Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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