NDLI: Use of acetylcholinesterase, glutathione S-transferase and cytochrome P450 1A1 in Capoeta umbla as biomarkers for monitoring of pollution in Uzuncayir Dam Lake (Tunceli, Turkey).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yildirim, Nuran Cikcikoglu Yildirim, Numan Danabas, Durali Danabas, Seval
Spatial Coverage	Turkey
Description	Author Affiliation: Yildirim NC ( Tunceli University, Faculty of Engineering, Department of Environmental Engineering, 62000 Tunceli, Turkey. Electronic address: nurancyildirim@tunceli.edu.tr.); Yildirim N ( Tunceli University, Faculty of Engineering, Department of Environmental Engineering, 62000 Tunceli, Turkey.); Danabas D ( Tunceli University, Fisheries Faculty, TR62000 Tunceli, Turkey.); Danabas S ( Tunceli University, Faculty of Engineering, Department of Environmental Engineering, 62000 Tunceli, Turkey.)
Abstract	Uzuncayir Dam Lake is one of the most important water bodies in Tunceli. It is polluted by domestic wastewaters together with natural contamination and pesticides, which have had cumulatively negative effects. This study analyzes the effects of pollution by using the fish species, Capoeta umbla as a sentinel species, with a biomarker approach. The approach comprehends a general biomarker of individual fish health, the condition factor and specific biomarkers of contaminant exposure such as glutathione S-transferase (GST) and cytochrome P450 1A1 (CYP1A1) and acetylcholinesterase (AChE) activity. The general water physico-chemical parameters were measured at each sampling sites during each fish-sampling period. Strong seasonal and locational variations were observed among selected markers. In conclusion, the multibiomarker approach used in the present study clearly revealed differences in the fish health among reference and potentially contaminated sites. The study shows that changes of biomarkers such as acetylcholinesterase, glutathione S-transferase and cytochrome P450 1A1 might be useful for the assessment of environmental contamination in the Uzuncayir Dam Lake (Tunceli, Turkey).
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Acetylcholinesterase Metabolism Cyprinidae Gills Drug Effects Glutathione Transferase Liver Water Pollutants, Chemical Toxicity Animals Biological Markers Cytochrome P-450 Cyp1a1 Environmental Monitoring Methods Enzymology Lakes Turkey Water Pollution Adverse Effects Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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