NDLI: Cytotoxic effects of three new metabolites from Red Sea marine sponge, Petrosia sp.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abdel-Lateff, Ahmed Alarif, Walied M. Asfour, Hany Z. Ayyad, Seif-Eldin N. Khedr, Alaa Badria, Farid A. Al-Lihaibi, Sultan S.
Spatial Coverage	Indian Ocean
Description	Country affiliation: Egypt Author Affiliation: Abdel-Lateff A ( Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, PO Box 80260, Jeddah 21589, Saudi Arabia); Alarif WM ( Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO. Box 80207, Jeddah 21589, Saudi Arabia. Electronic address: walied1737@yahoo.com.); Asfour HZ ( Department of Pharmaceutical Chemistry and Phytochemistry, Faculty of Pharmacy, King Abdulaziz University, PO Box 80260, Jeddah 21589, Saudi Arabia.); Ayyad SE ( Department of Chemistry, Faculty of Science, King Abdulaziz University, PO. Box 80203, Jeddah 21589, Saudi Arabia); Khedr A ( Department of Pharmaceutical Chemistry and Phytochemistry, Faculty of Pharmacy, King Abdulaziz University, PO Box 80260, Jeddah 21589, Saudi Arabia.); Badria FA ( Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.); Al-Lihaibi SS ( Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO. Box 80207, Jeddah 21589, Saudi Arabia.)
Abstract	Marine sponges represent an affluent source of biogenetically unprecedented array of biologically active compounds. This study revealed the isolation of ten compounds from marine sponge of Petrosia sp. Their chemical structures were determined by using 1D and 2D NMR, UV, IR and MS measurements. A polyoxygenated steroid (3ß,7ß,9 -trihydroxycholest-5-en (1), a purine-derivative (3,7-dimethyl-2-(methylamino)-3H-purin-6(7H)-one (2) and a sphingolipid (N-((3S,E)-1,3-dihydroxytetracos-4-en-2-yl)stearamide (3) proved to be new compounds. Meanwhile, seven known compounds; (4-10) were also identified. The cytotoxicity of the total extract and the isolated compounds were subjected to cytotoxicity evaluation employing two cancer cell lines; HepG2 and MCF-7. All tested compounds exhibited cytotoxic effect on both cancer cell lines with IC(50) in range of 20-500 µM. The proposed mechanism of cytotoxic activities was examined through its molecular affinity to the DNA. Compound 5 showed the highest affinity to the DNA with IC(50) 30 µg/mL.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Cytotoxins Pharmacology Marine Toxins Porifera Chemistry Animals Isolation & Purification Dna Metabolism Hep G2 Cells Humans Indian Ocean Mcf-7 Cells Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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