NDLI: Antioxidant biomarker survey ensuing long-term selenium withdrawal in Acipenser baeri fed Se-cysteine diets.

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Antioxidant biomarker survey ensuing long-term selenium withdrawal in Acipenser baeri fed Se-cysteine diets.

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Antioxidant biomarker survey ensuing long-term selenium withdrawal in Acipenser baeri fed Se-cysteine diets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elia, Antonia Concetta Abete, Maria Cesarina Pacini, Nicole Dörr, Ambrosius Josef Martin Scanzio, Tommaso Prearo, Marino
Description	Author Affiliation: Elia AC ( Department of Cellular and Environmental Biology, University of Perugia, 06123 Perugia, Italy. Electronic address: antonia.elia@unipg.it.); Abete MC ( C.Re.A.A. National Reference Centre for the Surveillance and Monitoring of Animal Feed, State Veterinary Institute, 10154 Turin, Italy.); Pacini N ( Department of Cellular and Environmental Biology, University of Perugia, 06123 Perugia, Italy.); Dörr AJ ( Department of Cellular and Environmental Biology, University of Perugia, 06123 Perugia, Italy.); Scanzio T ( Fish Disease Laboratory, State Veterinary Institute, 10154 Turin, Italy.); Prearo M ( Fish Disease Laboratory, State Veterinary Institute, 10154 Turin, Italy.)
Abstract	Two selenium withdrawal periods, 30 and 90 days, were considered for sturgeon fed 90 days three Se-cysteine diets (1.25, 5, 20 mgkg(-1)). Subsequently Acipenser baeri was fed the previous control diet (0.32 mgSekg(-1)) for 90 days. Levels of superoxide dismutase, catalase, glutathione peroxidases, glutathione reductase, glyoxalase-II and malondialdehyde were determined in liver and kidney. Chemical analyses were carried out for the same tissues and for muscle. A reduction of Se levels in all tissues was recorded and the metalloid concentration decreased more quickly in liver than in kidney and muscle. At the end of the withdrawal Se concentration in muscle remained high in specimens previously fed 20 mgSekg(-1) diet, and disturbance of key antioxidant enzymes was recorded in liver and kidney. Moreover, alterations in glutathione peroxidases, and glyoxalase-II activities persisted even after 90 withdrawal days and were indicative of oxidative stress induced by Se-cysteine concentrations.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Antioxidants Pharmacokinetics Fishes Metabolism Selenium Selenocysteine Animals Administration & Dosage Biological Markers Catalase Diet Glutathione Peroxidase Kidney Liver Malondialdehyde Muscles Oxidative Stress Superoxide Dismutase Thiolester Hydrolases Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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