NDLI: Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron $discharge^{†}$

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Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron $discharge^{†}$

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Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron $discharge^{†}$

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lopez-Santos, C. Colaux, J. L. Laloy, J. Fransolet, M. Mullier, F. Michiels, C. Dogné, J-M Lucas, S.
Description	Country affiliation: Belgium Author Affiliation: Lopez-Santos C ( Namur Research Institute for Life Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur (FUNDP), Namur, Belgium. mclopezs@fundp.ac.be)
Abstract	Literature contains very few data about the potential biomedical application of amorphous hydrogenated carbon (a-C:H) thin films deposited by reactive pulsed magnetron discharge even so it is one of the most scalable plasma deposition technique. In this article, we show that such a $C_{2}H_{2}$ pulsed magnetron plasma produces high quality coating with good hemocompatibility and bioactive response: no effect on hemolysis and hemostasis were observed, and proliferation of various cell types such as endothelial, fibroblast, and osteoblast-like cells was not affected when the deposition conditions were varied. Cell growth on a-C:H coatings is proposed to take place by a two-step process: the initial cell contact is affected by the smooth topography of the a-C:H coatings, whereas the polymeric-like structure, together with a moderate hydrophilicity and a high hydrogen content, directs the posterior cell spreading while preserving the hemocompatible behavior. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
File Format	HTM / HTML
ISSN	15493296
Issue Number	6
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Research Support, Non-u.s. Gov't Cell Proliferation Endothelial Cells Humans Cytology Erythrocytes Hydrogenation Interleukin-8 Osteoblasts Journal Article Wettability Ultrastructure Cell Shape Fibroblasts Microscopy, Atomic Force Hydrocarbons, Iodinated Hemolysis Actin Cytoskeleton Cell Line Photoelectron Spectroscopy Surface Tension Cell Survival Secretion Blood Platelets Materials Testing Coated Materials, Biocompatible Pharmacology Metabolism Drug Effects Discipline Biomedical Engineering Chemistry Magnetic Fields
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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