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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fooladi, Abbas Ali Imani Hosseini, Hamideh Mahmoodzadeh Hafezi, Forough Hosseinnejad, Fatemeh Nourani, Mohammad Reza |
| Description | Country affiliation: Iran Author Affiliation: Fooladi AA ( Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.) |
| Abstract | Bioactive glass (BG) composites with a base of SiO2-Na2O-CaO-P2O5 are biocompatible biomaterials. The assessment of their abilities for medical applications has interested researchers. We produced a BG-containing SiO2-MgO-CaO-P2O5 by the sol-gel method. To determine the antibacterial effects, we analyzed the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) properties of this product on three microorganisms, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, known causative agents for biofilm formation on implant surfaces. In addition, we performed the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to study the cytotoxic effects of our composite on animal cells. Our results demonstrated that our BG product inhibited the growth of bacteria in a concentration-dependent manner without any cytotoxic effects. Therefore, our BG product can be utilized as an appropriate implant for treating bone and tooth defects. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 6 |
| Volume Number | 101 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Staining And Labeling X-ray Diffraction Cricetulus Glass Phase Transition Journal Article Tissue Scaffolds Microbial Sensitivity Tests Nanoparticles Escherichia Coli Ultrastructure Trypan Blue Staphylococcus Aureus Cricetinae Powders Cell Survival Pharmacology Cho Cells Pseudomonas Aeruginosa Metabolism Drug Effects Anti-bacterial Agents Discipline Biomedical Engineering Chemistry Animals |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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