NDLI: Self-assembly of model graft copolymers of agarose and weak polyelectrolyte-based amphiphilic diblock copolymers: controlled drug release and degradation.

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Self-assembly of model graft copolymers of agarose and weak polyelectrolyte-based amphiphilic diblock copolymers: controlled drug release and degradation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Muppalla, Ravikumar Jewrajka, Suresh K. Prasad, Kamalesh
Description	Country affiliation: India Author Affiliation: Muppalla R ( Reverse Osmosis Discipline, CSIR-Central Salt and Marine Chemicals Research Institute, G B Marg, Bhavnagar, Gujarat-364002, India.)
Abstract	Polysaccharide-based copolymers are promising biomaterials due to their biocompatibility and biodegradability. For potential biomedical applications the copolymer as a whole and all the degraded species must be biocompatible and easily removable from the system. In this regards, new model pH-responsive seaweed agarose (Agr) grafted with weak polyelectrolyte-based well-defined amphiphilic block copolymers ca. poly[(methyl methacrylate)-b-(2-dimethylamino)ethyl methacrylate)] (PMMA-b-PDMA) were designed and synthesized to study the self-assembly, degradation, and in vitro hydrophobic/hydrophilic drug release behavior. The graft copolymer solutions display extremely low critical micelle concentration (CMC) and form pH responsive stable micelles. The degradation study of the graft copolymer reveals that the entire degraded components are well soluble/dispersible in water due to formation of mixed micelles. The micelles are also strongly adsorbed on the mica surface owing to electrostatic interaction. One application of the graft copolymer micelles is that it can entrap both hydrophilic and poorly water soluble hydrophobic drugs effectively and exhibit slow release kinetics. The release kinetics of both the hydrophilic and poorly water soluble hydrophobic drugs change with pH as well as with the composition of the graft copolymer.
File Format	HTM / HTML
ISSN	15493296
Issue Number	6
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Methacrylates Research Support, Non-u.s. Gov't Sepharose Delayed-action Preparations Polymethyl Methacrylate Journal Article Methylmethacrylates Spectrophotometry, Infrared Micelles Microscopy, Atomic Force Hydrogen-ion Concentration Buffers Prednisolone Surface-active Agents Surface Tension Magnetic Resonance Spectroscopy Solubility Hydrodynamics Chemical Synthesis Pharmacology Drug Effects Discipline Biomedical Engineering Chemistry Ethylamines Electrolytes Chromatography, Gel Analogs & Derivatives
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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