NDLI: High biocompatibility and improved osteogenic potential of novel Ca-P/titania composite scaffolds designed for regeneration of load-bearing segmental bone defects.

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High biocompatibility and improved osteogenic potential of novel Ca-P/titania composite scaffolds designed for regeneration of load-bearing segmental bone defects.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cunha, Carla Sprio, Simone Panseri, Silvia Dapporto, Massimiliano Marcacci, Maurilio Tampieri, Anna
Description	Country affiliation: Italy Author Affiliation: Cunha C ( Laboratory of Bioceramics and Bio-hybrid Composites, Institute of Science and Technology for Ceramics, National Research Council, Faenza 48018, Italy. carla.cunha@ineb.up.pt)
Abstract	Regeneration of load-bearing bone segments is still an open challenge due to the lack of biomaterials mimicking natural bone with a suitable chemicophysical and mechanical performance. This study proposes ceramic bone scaffolds made of ß-tricalcium phosphate (ß-TCP) and titania (TiO2 ), developed from hydroxyapatite (HA) and TiO2 starting nanopowders, which exhibit high and interconnected macroporosity (>70 vol %). The scaffold composition was designed to achieve a synergistic effect of bioactivity/resorbability and mechanical properties suitable for load-bearing regenerative applications. The analysis of the morphology, structure, and mechanical strength of the scaffolds resulted in compression strength nearly twice that of commercially available HA bone grafts with similar structure (Engipore(®)). Biological characterization was carried out for human MG-63 osteoblast-like cells proliferation, activity, attachment, and viability. ß-TCP/TiO2 scaffolds show high proliferation rate, high viability, and high colonization rates. Moreover, an increased activity of the osteogenic marker alkaline phosphatase (ALP) was found. These results demonstrate that ß-TCP/TiO2 scaffolds have good potential as osteogenically active load-bearing scaffolds; moreover, given the high and interconnected macroporosity as well as the resorbability properties of ß-TCP, these scaffolds may enhance in vivo osteointegration and promote the formation of new organized bone, thus resulting in very promising biomimetic scaffolds for long bone regeneration.
File Format	HTM / HTML
ISSN	15493296
Issue Number	6
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Durapatite Research Support, Non-u.s. Gov't Temperature X-ray Diffraction Cell Proliferation Humans Cytology Alkaline Phosphatase Osteoblasts Journal Article Tissue Scaffolds Calcium Phosphates Ultrastructure Bone And Bones Titanium Weight-bearing Cell Survival Materials Testing Pharmacology Bone Regeneration Metabolism Drug Effects Physiopathology Discipline Biomedical Engineering Pathology Chemistry Biocompatible Materials Porosity Enzymology Osteogenesis
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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