NDLI: In vitro cytotoxicity and in vivo osseointergration properties of compression-molded $HDPE-HA-Al_{2}O_{3}$ hybrid $biocomposites^{†}$

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In vitro cytotoxicity and in vivo osseointergration properties of compression-molded $HDPE-HA-Al_{2}O_{3}$ hybrid $biocomposites^{†}$

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In vitro cytotoxicity and in vivo osseointergration properties of compression-molded $HDPE-HA-Al_{2}O_{3}$ hybrid $biocomposites^{†}$

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tripathi, Garima Gough, Julie E. Dinda, Amit Basu, Bikramjit
Description	Country affiliation: India Author Affiliation: Tripathi G ( Department of Materials Science and Engineering, Laboratory for Biomaterials, Indian Institute of Technology, Kanpur 208016, Uttra Pradesh, India.)
Abstract	The aim of this study was to investigate the in vivo biocompatibility in terms of healing of long segmental bone defect in rabbit model as well as in vitro cytotoxicity of eluates of compression-molded High density polyethylene (HDPE)–hydroxyapatite (HA)-aluminum oxide $(Al_{2}O_{3})$ composite-based implant material. Based on the physical property in terms of modulus and strength properties, as reported in our recent publication, HDPE-40 wt % HA and HDPE-20 wt % HA-20 wt % $Al_{2}O_{3}$ hybrid composites were used for biocompatibility assessment. Osteoblasts cells were cultured in conditioned media, which contains varying amount of composite eluate (0.01, 0.1, and 1.0 wt %). In vitro, the eluates did not exhibit any significant negative impact on proliferation, mineralization or on morphology of human osteoblast cells. In vivo, the histological assessment revealed neobone formation at the bone/implant interface, characterized by the presence of osteoid and osteoblasts. The observation of osteoclastic activity indicates the process of bone remodeling. No inflammation to any noticeable extent was observed at the implantation site. Overall, the combination of in vitro and in vivo results are suggestive of potential biomedical application of compression-molded HDPE- 20 wt % HA- 20 wt % $Al_{2}O_{3}$ composites to heal long segmental bone defects without causing any toxicity of bone cells. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
File Format	HTM / HTML
ISSN	15493296
Issue Number	6
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Durapatite Osseointegration Research Support, Non-u.s. Gov't Oxazines X-ray Diffraction Cell Count Humans Cytology Aluminum Oxide Osteoblasts Journal Article Ultrastructure Cell Shape Bone And Bones Cell Death Rabbits Polyethylene Microscopy, Electron, Scanning Implants, Experimental Cell Survival Materials Testing Pharmacology Metabolism Drug Effects Discipline Biomedical Engineering Compressive Strength Xanthenes Culture Media, Conditioned Animals Anthraquinones Calcification, Physiologic Biocompatible Materials
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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