| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Steinmaus, Craig Ferreccio, Catterina Acevedo, Johanna Yuan, Yan Liaw, Jane Durán, Viviana Cuevas, Susana García, José Meza, Rodrigo Valdés, Rodrigo Valdés, Gustavo Benítez, Hugo VanderLinde, Vania Villagra, Vania Cantor, Kenneth P. Moore, Lee E. Perez, Saida G. Steinmaus, Scott Smith, Allan H. |
| Spatial Coverage |
Chile |
| Description |
Author Affiliation: Steinmaus C ( Arsenic Health Effects Research Program, University of California, Berkeley, Berkeley); Ferreccio C ( Pontificia Universidad Catolica de Chile, Facultad de Medicina, CENTRO FONDAP/ACCDIS, Santiago, Chile.); Acevedo J ( Pontificia Universidad Catolica de Chile, Facultad de Medicina, CENTRO FONDAP/ACCDIS, Santiago, Chile.); Yuan Y ( Arsenic Health Effects Research Program, University of California, Berkeley, Berkeley); Liaw J ( Arsenic Health Effects Research Program, University of California, Berkeley, Berkeley); Durán V ( Hospital Regional de Arica Dr. Juan Noé); Cuevas S ( Centro de Salud Familiar Iris Veliz Hume, Arica); García J ( Hospital Regional de Iquique Dr. Ernesto Torres Galdames, Iquique); Meza R ( Hospital Regional de Calama, Calama); Valdés R ( Laboratorio Histonor); Valdés G ( Laboratorio Histonor); Benítez H ( Hospital Regional de Antofagasta Dr. Leonardo Guzmán, Antofagasta); VanderLinde V ( Hospital Regional de Antofagasta Dr. Leonardo Guzmán, Antofagasta); Villagra V ( Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago); Cantor KP ( KP Cantor Environmental LLC, Silver Springs); Moore LE ( National Cancer Institute, Bethesda, Maryland); Perez SG ( Global Health Sciences Program, University of California, San Francisco, San Francisco); Steinmaus S ( Biological Sciences Department, California Polytechnic State University, San Luis Obispo, California); Smith AH ( Arsenic Health Effects Research Program, University of California, Berkeley, Berkeley) |
| Abstract |
BACKGROUND: From 1958 to 1970, >100,000 people in northern Chile were exposed to a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life exposure in this population resulted in increased mortality in adults from several outcomes, including lung and bladder cancer. METHODS: We have now completed the first study ever assessing incident cancer cases after early-life arsenic exposure, and the first study on this topic with individual participant exposure and confounding factor data. Subjects included 221 lung and 160 bladder cancer cases diagnosed in northern Chile from 2007 to 2010, and 508 age and gender-matched controls. RESULTS: ORs adjusted for age, sex, and smoking in those only exposed in early life to arsenic water concentrations of ≤110, 110 to 800, and >800 µg/L were 1.00, 1.88 [95% confidence interval (CI), 0.96-3.71], and 5.24 (3.05-9.00; P(trend) < 0.001) for lung cancer, and 1.00, 2.94 (1.29-6.70), and 8.11 (4.31-15.25; P(trend) < 0.001) for bladder cancer. ORs were lower in those not exposed until adulthood. The highest category (>800 µg/L) involved exposures that started 49 to 52 years before, and ended 37 to 40 years before the cancer cases were diagnosed. CONCLUSION: Lung and bladder cancer incidence in adults was markedly increased following exposure to arsenic in early life, even up to 40 years after high exposures ceased. Such findings have not been identified before for any environmental exposure, and suggest that humans are extraordinarily susceptible to early-life arsenic exposure. IMPACT: Policies aimed at reducing early-life exposure may help reduce the long-term risks of arsenic-related disease. |
| File Format |
HTM / HTML |
| ISSN |
10559965 |
| e-ISSN |
15387755 |
| DOI |
10.1158/1055-9965.EPI-14-0059 |
| Journal |
Cancer Epidemiology Biomarkers & Prevention |
| Issue Number |
8 |
| Volume Number |
23 |
| Language |
English |
| Publisher |
American Association for Cancer Research |
| Publisher Date |
2014-08-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Cancer epidemiology Arsenic Adverse Effects Environmental Exposure Lung Neoplasms Epidemiology Urinary Bladder Neoplasms Water Pollutants, Chemical Arsenic Poisoning Chile Pregnancy Prenatal Exposure Delayed Effects Chemically Induced Water Pollution, Chemical Research Support, N.i.h., Extramural |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Epidemiology Oncology |
