| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Jung, Seungyoun Qian, Zhi Rong Yamauchi, Mai Bertrand, Kimberly A. Fitzgerald, Kathryn C. Inamura, Kentaro Kim, Sun A. Mima, Kosuke Sukawa, Yasutaka Zhang, Xuehong Wang, Molin Smith-Warner, Stephanie A. Wu, Kana Fuchs, Charles S. Chan, Andrew T. Giovannucci, Edward L. Ng, Kimmie Cho, Eunyoung Ogino, Shuji Nishihara, Reiko |
| Description |
Author Affiliation: Jung S ( Channing Division of Network Medicine, Department of Medicine and.); Qian ZR ( Department of Medical Oncology, Dana-Farber Cancer Institute); Yamauchi M ( Department of Medical Oncology, Dana-Farber Cancer Institute); Bertrand KA ( Channing Division of Network Medicine, Department of Medicine and.); Fitzgerald KC ( Epidemiology.); Inamura K ( Department of Medical Oncology, Dana-Farber Cancer Institute); Kim SA ( Department of Medical Oncology, Dana-Farber Cancer Institute); Mima K ( Department of Medical Oncology, Dana-Farber Cancer Institute); Sukawa Y ( Department of Medical Oncology, Dana-Farber Cancer Institute); Zhang X ( Channing Division of Network Medicine, Department of Medicine and.); Wang M ( Epidemiology, Biostatistics, and.); Smith-Warner SA ( Epidemiology, Nutrition, Harvard School of Public Health, Boston, Massachusetts); Wu K ( Nutrition, Harvard School of Public Health, Boston, Massachusetts); Fuchs CS ( Channing Division of Network Medicine, Department of Medicine and Department of Medical Oncology, Dana-Farber Cancer Institute); Chan AT ( Channing Division of Network Medicine, Department of Medicine and Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School); Giovannucci EL ( Channing Division of Network Medicine, Department of Medicine and Epidemiology, Nutrition, Harvard School of Public Health, Boston, Massachusetts); Ng K ( Department of Medical Oncology, Dana-Farber Cancer Institute); Cho E ( Channing Division of Network Medicine, Department of Medicine and Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.); Ogino S ( Department of Pathology, Brigham and Women's Hospital and Department of Medical Oncology, Dana-Farber Cancer Institute); Nishihara R ( Department of Medical Oncology, Dana-Farber Cancer Institute) |
| Abstract |
BACKGROUND: Despite accumulating evidence for the preventive effect of vitamin D on colorectal carcinogenesis, its precise mechanisms remain unclear. We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression. METHODS: Among 140,418 participants followed from 1986 through 2008 in the Nurses' Health Study and the Health Professionals' Follow-up Study, we identified 1,059 incident colorectal cancer cases with tumor molecular data. The predicted 25-hydroxyvitamin D [25(OH)D] score was developed using the known determinants of plasma 25(OH)D. We estimated the HR for cancer subtypes using the duplication method Cox proportional hazards model. RESULTS: A higher predicted 25(OH)D score was associated with a lower risk of colorectal cancer irrespective of VDR expression level (P(heterogeneity) for subtypes = 0.75). Multivariate HRs (95% confidence intervals) comparing the highest with the lowest quintile of predicted 25(OH)D scores were 0.48 (0.30-0.78) for VDR-negative tumor and 0.56 (0.42-0.75) for VDR-positive tumor. Similarly, the significant inverse associations of the predicted 25(OH)D score with colorectal cancer risk did not significantly differ by KRAS, BRAF, or PIK3CA status (P(heterogeneity) for subtypes ≥ 0.22). CONCLUSIONS: A higher predicted vitamin D score was significantly associated with a lower colorectal cancer risk, regardless of VDR status and other molecular features examined. IMPACT: The preventive effect of vitamin D on colorectal carcinogenesis may not totally depend on tumor factors. Host factors (such as local and systemic immunity) may need to be considered. |
| File Format |
HTM / HTML |
| ISSN |
10559965 |
| e-ISSN |
15387755 |
| DOI |
10.1158/1055-9965.EPI-14-0229 |
| Journal |
Cancer Epidemiology Biomarkers & Prevention |
| Issue Number |
8 |
| Volume Number |
23 |
| Language |
English |
| Publisher |
American Association for Cancer Research |
| Publisher Date |
2014-08-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Cancer epidemiology Colorectal Neoplasms Epidemiology Metabolism Receptors, Calcitriol Biosynthesis Vitamin D Analogs & Derivatives Immunohistochemistry Polymerase Chain Reaction Risk Factors Blood Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Epidemiology Oncology |
