| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Gritz, Ellen R. Arnold, Kathryn B. Moinpour, Carol M. Burton-Chase, Allison M. Tangen, Catherine M. Probstfield, Jeffrey F. See, William A. Lieber, Michael M. Caggiano, Vincent Moody-Thomas, Sarah Szczepanek, Connie Ryan, Anne Carlin, Susie Hill, Shannon Goodman, Phyllis J. Padberg, Rose Mary Minasian, Lori M. Meyskens, Frank L. Thompson, Ian M. |
| Description |
Author Affiliation: Gritz ER ( Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston); Arnold KB ( SWOG Statistical Center); Moinpour CM ( Division of Public Health Sciences, Fred Hutchinson Cancer Research Center); Burton-Chase AM ( Department of Basic and Social Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York); Tangen CM ( SWOG Statistical Center); Probstfield JF ( Department of Medicine, University of Washington, Kirkland); See WA ( Division of Urology, Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin); Lieber MM ( Department of Urology, Mayo Clinic, Rochester, Minnesota); Caggiano V ( Sutter Institute for Medical Research, Sacramento); Moody-Thomas S ( School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana); Szczepanek C ( Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan); Ryan A ( Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland); Carlin S ( C3 Research Associates, Seattle); Hill S ( Bothell, Washington); Goodman PJ ( SWOG Statistical Center); Padberg RM ( Arlington Free Clinic, Arlington, Virginia.); Minasian LM ( Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland); Meyskens FL ( Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California); Thompson IM ( Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Texas) |
| Abstract |
BACKGROUND: The Prostate Cancer Prevention Trial (PCPT) was a 7-year randomized, double-blind, placebo-controlled trial of the efficacy of finasteride for the prevention of prostate cancer with a primary outcome of histologically determined prevalence of prostate cancer at the end of 7 years. METHODS: A systematic modeling process using logistic regression identified factors available at year 6 that are associated with end-of-study (EOS) biopsy adherence at year 7, stratified by whether participants were ever prompted for a prostate biopsy by year 6. Final models were evaluated for discrimination. At year 6, 13,590 men were available for analysis. RESULTS: Participants were more likely to have the EOS biopsy if they were adherent to study visit schedules and procedures and/or were in good health (P < 0.01). Participants at larger sites and/or sites that received retention and adherence grants were also more likely to have the EOS biopsy (P < 0.05). CONCLUSIONS: Our results show good adherence to study requirements 1 year before the EOS biopsy was associated with greater odds that a participant would comply with the invasive EOS requirement. IMPACT: Monitoring adherence behaviors may identify participants at risk of nonadherence to more demanding study end points. Such information could help frame adherence intervention strategies in future trials. |
| File Format |
HTM / HTML |
| ISSN |
10559965 |
| e-ISSN |
15387755 |
| DOI |
10.1158/1055-9965.EPI-14-0202 |
| Journal |
Cancer Epidemiology Biomarkers & Prevention |
| Issue Number |
8 |
| Volume Number |
23 |
| Language |
English |
| Publisher |
American Association for Cancer Research |
| Publisher Date |
2014-08-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Cancer epidemiology Biopsy Patient Compliance Statistics & Numerical Data Prostatic Neoplasms Prevention & Control Research Design 5-alpha Reductase Inhibitors Therapeutic Use Double-blind Method Finasteride Roc Curve Multicenter Study Randomized Controlled Trial Research Support, N.i.h., Extramural |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Epidemiology Oncology |
