NDLI: Family history of colorectal cancer is not associated with colorectal cancer survival regardless of microsatellite instability status.

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Family history of colorectal cancer is not associated with colorectal cancer survival regardless of microsatellite instability status.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Phipps, Amanda I. Ahnen, Dennis J. Campbell, Peter T. Win, Aung Ko Jenkins, Mark A. Lindor, Noralane M. Gryfe, Robert Potter, John D. Newcomb, Polly A.
Description	Author Affiliation: Phipps AI ( Epidemiology Department, University of Washington); Ahnen DJ ( Division of Gastroenterology, University of Colorado School of Medicine, Denver, Colorado); Campbell PT ( Epidemiology Research Program, American Cancer Society, Atlanta, Georgia); Win AK ( Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia); Jenkins MA ( Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia); Lindor NM ( Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona); Gryfe R ( Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada); Potter JD ( Epidemiology Department, University of Washington); Newcomb PA ( Epidemiology Department, University of Washington)
Abstract	BACKGROUND: Individuals with a family history of colorectal cancer in first-degree relatives have an elevated risk of developing colorectal cancer themselves, particularly colorectal cancer exhibiting high microsatellite instability (MSI-high). Given that MSI-high colorectal cancer is associated with a favorable prognosis, it is plausible that having a family history of colorectal cancer could, in turn, be favorably associated with colorectal cancer survival. METHODS: This study comprised N = 4,284 incident colorectal cancer cases enrolled in the Colon Cancer Family Registry via population-based cancer registries. Using Cox proportional hazards regression, we evaluated the association between family history and both overall and disease-specific survival, accounting for MSI status and tumor site via stratified analyses and statistical adjustment. RESULTS: There was no evidence of association between family history and overall [hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.79-1.08] or disease-specific survival (HR, 1.03; 95% CI, 0.85-1.24) for all cases combined, after adjustment for MSI status or tumor site. Only for rectal cancer cases was colorectal cancer family history modestly associated with more favorable overall survival (HR, 0.75; 95% CI, 0.56-0.99). CONCLUSIONS: Although individuals with a family history of colorectal cancer were more likely to have MSI-high tumors than those with nonfamilial disease, this did not translate to a survival benefit. IMPACT: Overall, there is no evidence that family history of colorectal cancer is associated with colorectal cancer survival; however, specific mechanisms underlying family history may have prognostic impact and merit further study.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-14-0533
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	8
Volume Number	23
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Colorectal Neoplasms Genetics Mortality Microsatellite Instability Proportional Hazards Models Registries Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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