| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Wilson, Carmen L. Stratton, Kayla Leisenring, Wendy L. Oeffinger, Kevin C. Nathan, Paul C. Wasilewski-Masker, Karen Hudson, Melissa M. Castellino, Sharon M. Stovall, Marilyn Armstrong, Gregory T. Brinkman, Tara M. Krull, Kevin R. Robison, Leslie L. Ness, Kirsten K. |
| Description |
Author Affiliation: Wilson CL ( Departments of Epidemiology and Cancer Control.); Stratton K ( Division of Clinical Statistics and Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington); Leisenring WL ( Division of Clinical Statistics and Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington); Oeffinger KC ( Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York); Nathan PC ( Department of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada); Wasilewski-Masker K ( Department of Pediatrics, The Aflac Cancer & Blood Disorders Center at Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia); Hudson MM ( Departments of Epidemiology and Cancer Control, Oncology, and.); Castellino SM ( Department of Pediatrics, Section Hematology/Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina); Stovall M ( Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas.); Armstrong GT ( Departments of Epidemiology and Cancer Control.); Brinkman TM ( Departments of Epidemiology and Cancer Control, Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee); Krull KR ( Departments of Epidemiology and Cancer Control, Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee); Robison LL ( Departments of Epidemiology and Cancer Control.); Ness KK ( Departments of Epidemiology and Cancer Control, kiri.ness@stjude.org.) |
| Abstract |
BACKGROUND: We aimed to identify demographic and health-related predictors of declining physical activity levels over a four-year period among participants in the Childhood Cancer Survivor Study. METHODS: Analyses included 7,287 ≥5-year childhood cancer survivors and 2,107 siblings who completed multiple follow-up questionnaires. Participants were classified as active if they met the Centers for Disease Control and Prevention guidelines for physical activity. Generalized linear models were used to compare participants whose physical activity levels declined from active to inactive over the study to those who remained active. In addition, selected chronic conditions (CTCAE v4.03 Grade 3 and 4) were evaluated as risk factors in an analysis limited to survivors only. RESULTS: The median age at last follow-up among survivors and siblings was 36 (range, 21-58) and 38 (range, 21-62) years, respectively. The rate of decline did not accelerate over time among survivors when compared with siblings. Factors that predicted declining activity included body mass index ≥30 kg/m(2) [RR = 1.32; 95% confidence interval (CI), 1.19-1.46, P < 0.01], not completing high school (RR = 1.31; 95% CI, 1.08-1.60, P < 0.01), and female sex (RR = 1.33; 95% CI, 1.22-1.44, P < 0.01). Declining physical activity levels were associated with the presence of chronic musculoskeletal conditions (P = 0.034), but not with the presence of cardiac (P = 0.10), respiratory (P = 0.92), or neurologic conditions (P = 0.21). CONCLUSIONS: Interventions designed to maximize physical activity should target female, obese, and less educated survivors. Survivors with chronic musculoskeletal conditions should be monitored, counseled, and/or referred for physical therapy. IMPACT: Clinicians should be aware of low activity levels among subpopulations of childhood cancer survivors, which may heighten their risk for chronic illness. |
| File Format |
HTM / HTML |
| ISSN |
10559965 |
| e-ISSN |
15387755 |
| DOI |
10.1158/1055-9965.EPI-14-0213 |
| Journal |
Cancer Epidemiology Biomarkers & Prevention |
| Issue Number |
8 |
| Volume Number |
23 |
| Language |
English |
| Publisher |
American Association for Cancer Research |
| Publisher Date |
2014-08-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Cancer epidemiology Motor Activity Neoplasms Survivors Statistics & Numerical Data Cohort Studies Health Status Quality Of Life Retrospective Studies Questionnaires Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Epidemiology Oncology |
