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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wu, Chih-Ching Chang, Ya-Ting Chang, Kai-Ping Liu, Yu-Ling Liu, Hao-Ping Lee, I-Ling Yu, Jau-Song Chiang, Wei-Fan |
| Description | Author Affiliation: Wu CC ( Departments of Medical Biotechnology and Laboratory Science, College of Medicine, and Molecular Medicine Research Center, Chang Gung University, Tao-Yuan); Chang YT ( Molecular Medicine Research Center, Chang Gung University, Tao-Yuan); Chang KP ( Molecular Medicine Research Center, Chang Gung University, Tao-Yuan); Liu YL ( Molecular Medicine Research Center, Chang Gung University, Tao-Yuan); Liu HP ( Department of Veterinary Medicine, National Chung Hsing University, Taichung); Lee IL ( Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Liouying); Yu JS ( Cell and Molecular Biology, College of Medicine); Chiang WF ( Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Liouying) |
| Abstract | BACKGROUND: Oral cavity squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and its incidence is still increasing. Approximately 50% of patients with OSCC die within 5 years after diagnosis, mostly ascribed to the fact that the majority of patients present advanced stages of OSCC at the time of diagnosis. METHODS: To discover salivary biomarkers for ameliorating the detection of OSCC, herein, we developed a multiplexed bead-based platform to simultaneously detect auto-antibodies (auto-Abs) in salivary samples. RESULTS: Compared with healthy individuals, the salivary levels of anti-p53, anti-survivin, anti-Hsp60, and anti-RPLP0 were significantly elevated in patients with OSCC. Noteworthily, the elevated levels of anti-p53, anti-survivin, and anti-Hsp60 were already observed in individuals with oral potentially malignant disorder. Moreover, the salivary levels of anti-p53, anti-survivin, anti-Hsp60, anti-RPLP0, and anti-CK8 were significantly elevated in patients with early-stage OSCC compared with those in healthy individuals. Most importantly, the use of a combined panel of salivary anti-p53, anti-survivin, anti-Hsp60, and anti-RPLP0 largely improves the detection of OSCC. CONCLUSION: Collectively, our results reveal that the salivary auto-Abs are effective OSCC biomarkers and the four-auto-Ab panel provides a novel and practicable approach for OSCC screening. IMPACT: This study provides the first evidence for the potential clinical application of salivary auto-Abs in OSCC diagnosis. |
| File Format | HTM / HTML |
| ISSN | 10559965 |
| e-ISSN | 15387755 |
| Journal | Cancer Epidemiology Biomarkers & Prevention |
| Issue Number | 8 |
| Volume Number | 23 |
| Language | English |
| Publisher | American Association for Cancer Research |
| Publisher Date | 2014-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cancer epidemiology Antibodies, Neoplasm Tumor Markers, Biological Carcinoma, Squamous Cell Diagnosis Mouth Neoplasms Saliva Chemistry Autoantibodies Immunology Immunoassay Sensitivity And Specificity Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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