NDLI: Delivery of alloantigens via apoptotic cells generates dendritic cells with an immature tolerogenic phenotype.

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Pharmacogenetic study of ABCB1 and CYP3A5 genes during the first year following heart transplantation regarding tacrolimus or cyclosporine levels.

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Liver transplantation as treatment in a massive metastasis from Gruber-Frantz pancreatic tumor: a case report.

Effectiveness of different kidney exchange mechanisms to improve living donor transplantation in Chile.

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Late acute humoral rejection in low-risk renal transplant recipients induced with an interleukin-2 receptor antagonist and maintained with standard therapy: preliminary communication.

Cost-benefit estimation of cadaveric kidney transplantation: the case of a developing country.

Conversion to everolimus in liver transplant patients with renal dysfunction.

Long-term use of everolimus in lung transplant patients.

Malignancy development in lung transplant patients.

Prevalence of cardiac allograft vasculopathy assessed with coronary angiography versus coronary vascular ultrasound and virtual histology.

Delivery of alloantigens via apoptotic cells generates dendritic cells with an immature tolerogenic phenotype.

Retinoic acid generates regulatory T cells in experimental transplantation.

Alloantigen-specific response is preserved and autoimmunity is maintained in an HIV-positive patient with immunoglobulin A nephropathy undergoing renal transplantation: a warning about long-term reduction in immunosuppression--a case report.

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The excellent outcomes of ABO-incompatible kidney transplantation with high titer (>×2048) using anti-CD20 and anti-CD25 antibody without splenectomy: two case reports.

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De novo autoimmune hepatitis in Korean children after liver transplantation: a single institution's experience.

High mortality associated with Acinetobacter species infection in liver transplant patients.

Incidence and risk factors for the development of prolonged severe intrahepatic cholestasis after pediatric living-donor liver transplantation.

Current status of intestinal transplantation in Japan.

Kinetics of cellular and humoral immunity in a successful case of positive crossmatch kidney transplantation: a case report.

The treatment of deep vein thrombosis immediately after kidney transplantation: a case report.

A case of living-donor renal transplantation for chronic renal failure caused by secondary amyloidosis.

Concurrent inferior vena cava and hepatic vein stenoses after orthotopic liver transplantation: a case report.

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Advances in antibacterial therapy.

New technologies for infectious screening of organ donors.

Solid organ transplantation: the Italian experience in the international context.

Transplant tourism and donor-derived parasitic infections.

Controversies about induction therapy.

Infections and organ transplantation: new challenges for prevention and treatment of hepatitis C virus.

Epidemiology and outcome of hepatitis C relapse in transplant recipients.

Antifungal therapy.

Italian guidelines for diagnosis, prevention, and treatment of invasive fungal infections in solid organ transplant recipients.

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Delivery of alloantigens via apoptotic cells generates dendritic cells with an immature tolerogenic phenotype.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gleisner, M. A. Rosemblatt, M. Fierro, J. A. Bono, M. R.
Description	Country affiliation: Chile Author Affiliation: Gleisner MA ( Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.)
Abstract	BACKGROUND: Dendritic cells (DCs) are professional antigen-presenting cells able to induce immunity or tolerance. The interactions of immature DCs with naive T lymphocytes induce peripheral tolerance through mechanisms that include anergy or deletion of lymphocytes or the generation of regulatory T cells. Because of the central role of DCs in the immune response, they are potential targets for the induction of experimental tolerance. Thus, the generation of immature (tolerogenic) DCs able to capture and present alloantigens to T cells represents an important aim in our efforts to achieve better transplant acceptance. METHODS: In this work, we generated immature DCs by using vitamin D(3) (VD3) during the process of DC differentiation. RESULTS: The VD3-DCs showed an immature phenotype characterized by a low expression of major histocompatibility complex antigens of class II, CD86, and CD80 molecules and the secretion of a tolerogenic cytokine pattern. Furthermore, we showed that VD3-DCs phagocytose apoptotic allogeneic cells efficiently without inducing DC maturation or activation. Most important, our experiments demonstrated that mice treated with VD3 produce immature DCs in vivo, and that DCs from VD3-treated mice immunized with allogeneic apoptotic cells maintained their tolerogenic phenotype. CONCLUSION: Our results show that allogeneic apoptotic cells in combination with VD3 generate DCs with tolerogenic characteristics that could be used to induce tolerance towards alloantigens.
File Format	HTM / HTML
ISSN	00411345
Issue Number	6
Volume Number	43
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Apoptosis Dendritic Cells Immunology Immune Tolerance Isoantigens Phagocytosis Thymocytes Animals Antigens, Cd Antigens, Cd80 Antigens, Differentiation, Myelomonocytic Cell Differentiation Cells, Cultured Cholecalciferol Pharmacology Cytokines Metabolism Drug Effects Histocompatibility Antigens Class Ii Immunophenotyping Male Melanoma, Experimental Genetics Membrane Proteins Mice Mice, Inbred Balb C Mice, Inbred C57bl Necrosis Phenotype Pathology Transplantation Time Factors Transfection Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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