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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shin, M. Song, S. H. Kim, J. M. Kwon, C. H. Joh, J. W. Lee, S-K Kim, S-J |
| Spatial Coverage | Republic of Korea |
| Description | Author Affiliation: Shin M ( Department of Surgery, Division of Transplant Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) |
| Abstract | PURPOSE: Alemtuzumab (Campath-1H), a humanized monoclonal antibody directed against CD52, is a lymphocyte-depleting agent currently being evaluated as an induction agent in solid organ transplantation. This study analyzed the clinical outcomes and effects on peripheral blood lymphocyte subset counts in adult deceased donor renal transplant recipients who received an alemtuzumab-based induction protocol. METHODS: Eleven kidney alone or simultaneous pancreas-kidney transplant recipients received 20 mg alemtuzumab on postoperative days 0 and 1, followed by calcineurin inhibitor-based maintenance immunosuppression after postoperative day 5. We collected 1-year data including recipient and donor demographic features, renal function and adverse events including endocrine impact, incidence of acute rejection episodes, infections or malignancies as well as hematologic and late immunologic parameters for correlation with patient or graft survival. RESULTS: Mean HLA mismatch was 3.6 and 8/11 deceased donors were of the extended criteria type. Only 2 (18%) recipients displayed delayed graft function with a failure of the serum creatinine to decrease by 25% on the first day; however, their long-term outcomes were similar to other nonaffected patients. Serious adverse events were absent; there was no hyperlipidemia or new-onset diabetes. We failed to observe an acute rejection. The 3 (27%) recipients with infectious complications experienced pericardial tuberculosis, urinary tract infection, or invasive pulmonary aspergillosis. Two (18%) cases of posttransplantation lymphoproliferative disease were diagnosed in this study during the follow-up. Overall patient and graft survival rates were both 91%. CONCLUSION: This study demonstrated that preconditioning with antibody-depletion using alemtuzumab was efficient with satisfactory patient and graft survivals at 1 year. Alemtuzumab induction was safe even for recipients of extended criteria donor renal transplantation. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 6 |
| Volume Number | 43 |
| e-ISSN | 18732623 |
| Journal | Transplantation Proceedings |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Antibodies, Monoclonal, Humanized Therapeutic Use Antibodies, Neoplasm Immunosuppressive Agents Kidney Transplantation Adult Calcineurin Inhibitors Communicable Diseases Etiology Delayed Graft Function Drug Therapy, Combination Female Graft Rejection Prevention & Control Graft Survival Hla Antigens Immunology Histocompatibility Humans Adverse Effects Lymphoproliferative Disorders Male Middle Aged Pancreas Transplantation Prospective Studies Republic Of Korea Time Factors Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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