NDLI: Posttransplantation anemia: relationship with inflammatory markers, oxidation, and prohepcidin levels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sancho, A. Pastor, M. C. Cañas, L. Morales Indiano, C. Ardèvol, M. Aguerrevere, S. Juega, J. Romero, R. Lauzurica, R.
Spatial Coverage	Spain
Description	Country affiliation: Spain Author Affiliation: Sancho A ( Department of Biochemistry, Hospital Universitari Germans Trias I Pujol, Barcelona, Spain.)
Abstract	BACKGROUND: Anemia frequently occurs after kidney transplantation, its origin is multifactorial. The objective of this study was to evaluate the frequency of anemia among kidney transplantation patients at 3 months after transplantation and its relationship to inflammatory, oxidative, and nutritional states. Furthermore, we determined serum prohepcidin, a precursor of hepcidin, the main hormone implicated in iron metabolism. MATERIALS AND METHODS: We performed a transverse retrospective study in 130 patients who underwent kidney transplantation, including 89 men and 41 women. Patients were randomized according to the presence or absence of anemia at 3 months. The patients' inflammatory, oxidative, and nutritional states were evaluated as well as renal function and serum prohepcidin at 3 months. RESULTS: Twenty-four percent of the patients developed anemia at 3 months after transplantation. These patients presented with a greater inflammatory state, a poor nutritional status, and poor renal function. Serum prohepcidin was significantly lower compared with the transplantation patients who did not show anemia. CONCLUSIONS: Serum prohepcidin was significantly higher among kidney transplantation patients who did not develop anemia. The inflammatory state may be a determinant of the response to treatment with erythropoiesis-stimulating agents in anemic kidney transplant recipients.
File Format	HTM / HTML
ISSN	00411345
Issue Number	6
Volume Number	43
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Anemia Etiology Antimicrobial Cationic Peptides Blood Inflammation Mediators Inflammation Kidney Transplantation Adverse Effects Oxidative Stress Protein Precursors Adult Aged Drug Therapy Immunology Biological Markers Female Hematinics Therapeutic Use Hepcidins Humans Male Middle Aged Nutritional Status Retrospective Studies Spain Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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