NDLI: Prevalence of cardiac allograft vasculopathy assessed with coronary angiography versus coronary vascular ultrasound and virtual histology.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Torres, H. J. Merello, L. Ramos, S. A. Aninat, M. A. Becerra, L. E. Mora, A. D. Valenzuela, P. T. Godoy, M. J. Prieto, A. A.
Spatial Coverage	Chile
Description	Country affiliation: Chile Author Affiliation: Torres HJ ( Gustavo Fricke Hospital, Viña del Mar, Chile. torresh@gmail.com)
Abstract	BACKGROUND: Cardiac allograft vasculopathy (CAV) is a major factor limiting long-term survival after heart transplantation (HT). The purpose of this study was to characterize the coronary artery structure and to determine the prevalence of vasculopathy after HT, comparing the sensitivity of coronary angiography with that of intravascular ultrasound (IVUS) and virtual histology (VH). METHODS: A prospective recruitment cross-sectional study was performed in 31 adult HT recipients including 22 men and, 9 women of overall mean age of 45.2 ± 12.6 years at an average of 3.7 ± 3.7 years after transplantation. They underwent simultaneously coronary angiography and IVUS assessment of the left anterior descending coronary artery. We investigated histological composition of the intima. Final data were analyzed using parametric and nonparametric tests. RESULTS: IVUS discovered the presence of CAV among 17/31 (54.8%) patients versus coronary angiography in 10 (32.3%; P = .009). The histological composition of the intima as assessed with IVUS VH was 26.1% fiber, 8.7% necrotic core, 5.7% calcium, and 4.3% lipid. There was no significant association between preexistent risk factors and the presence of CAV. There was a correlation between time elapsed since HT and CAV development. CONCLUSION: Time elapsed since HT is the most important risk factor for the development of CAV. Its prevalence almost doubled when measured with IVUS in contrast with angiography. IVUS was thus shown to be a more sensitive diagnostic tool compared with coronary angiography.
File Format	HTM / HTML
ISSN	00411345
Issue Number	6
Volume Number	43
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Coronary Angiography Coronary Artery Disease Diagnosis Heart Transplantation Adverse Effects Ultrasonography, Interventional Adult Chile Epidemiology Pathology Cross-sectional Studies Female Humans Male Middle Aged Predictive Value Of Tests Prevalence Prospective Studies Risk Assessment Risk Factors Time Factors Transplantation, Homologous Treatment Outcome Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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