NDLI: Genotoxicity of low dose N-nitroso propoxur to human gastric cells.

Please wait, while we are loading the content...

Amelioration of anti-cancer agent adriamycin-induced nephrotic syndrome in rats by Wulingsan (Gorei-San), a blended traditional Chinese herbal medicine.

Variations in zearalenone activation in avian food species.

Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury.

Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats.

Lead induces oxidative stress, DNA damage and alteration of p53, Bax and Bcl-2 expressions in mice.

The anticancer effect of protein-extract from Bidens alba in human colorectal carcinoma SW480 cells via the reactive oxidative species- and glutathione depletion-dependent apoptosis.

Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells.

Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress.

Exposure data for cosmetic products: facial cleanser, hair conditioner, and eye shadow.

The identification of potential alternative biomarkers of nitrofurazone abuse in animal derived food products.

A comparative study on hypoglycemic and hypocholesterolemic effects of high and low molecular weight chitosan in streptozotocin-induced diabetic rats.

Polycyclic aromatic hydrocarbons in farmed rainbow trout (Oncorhynchus mykiss) processed by traditional flue gas smoking and by liquid smoke flavourings.

Long-term toxicity studies in dogs support the safety of the special extract ERr 731 from the roots of Rheum rhaponticum.

Reproductive and neurobehavioral outcome of drinking purified water under magnesium deficiency in the rat's diet.

Determination of aflatoxin B(1) levels in deep-red ground pepper (isot) using immunoaffinity column combined with ELISA.

A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome.

Contribution of fish consumption to heavy metals exposure in women of childbearing age from a Mediterranean country (Spain).

Estimation of hydroxymethylfurfural availability in breakfast cereals. Studies in Caco-2 cells.

Warfarin overdose due to the possible effects of Lycium barbarum L.

Assessment of the phototoxic potential of cosmetic products.

Dimethylamine and diet.

Assessment of dioxin and dioxin-like compounds in mainstream smoke from selected US cigarette brands and reference cigarettes.

Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats.

Edible safety requirements and assessment standards for agricultural genetically modified organisms.

Migration of BADGE (bisphenol A diglycidyl-ether) and BFDGE (bisphenol F diglycidyl-ether) in canned seafood.

Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice.

Mechanisms of star fruit-induced acute renal failure.

Interpretation of the pharmacokinetics of ochratoxin A in blood plasma of rats, during and after acute or chronic ingestion.

In vitro and in vivo safety studies of a proprietary whey extract.

Dietary fats modulate methylmercury-mediated systemic oxidative stress and oxidative DNA damage in rats.

Correlation of urinary furan with plasma gamma-glutamyltranspeptidase levels in healthy men and women.

Risk management and risk assessment of novel plant foods: concepts and principles.

Cytoprotective effect of baicalein against peroxynitrite-induced toxicity in LLC-PK(1) cells.

Effect of acute lindane and alcohol intoxication on serum concentration of enzymes and fatty acids in rats.

Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats.

Beneficial effect of shallot (Allium ascalonicum L.) extract on cyclosporine nephrotoxicity in rats.

Measurement of 16 polycyclic aromatic hydrocarbons in narghile waterpipe tobacco smoke.

Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells.

Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice.

Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocol.

Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: in vitro and in vivo study.

Food safety evaluation of broccoli and radish sprouts.

Chemical composition, and antioxidant and antimicrobial activities of three hazelnut (Corylus avellana L.) cultivars.

Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice.

Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae.

Accumulation and depuration of the synthetic antioxidant ethoxyquin in the muscle of Atlantic salmon (Salmo salar L.).

Genotoxicity of low dose N-nitroso propoxur to human gastric cells.

Lipid metabolism in liver of rat exposed to cadmium.

Probabilistic risk assessment model for allergens in food: sensitivity analysis of the minimum eliciting dose and food consumption.

Year: 2008 Volume: 46 Issue: 4

Year: 2008 Volume: 46 Issue: 3

Year: 2008 Volume: 46 Issue: 2

Year: 2008 Volume: 46 Issue: Supplementary 2

Year: 2008 Volume: 46 Issue: 1

Year: 2008 Volume: 46 Issue: Supplementary 1

Year: 2007 Volume: 45

Year: 2006 Volume: 44

Genotoxicity of low dose N-nitroso propoxur to human gastric cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kuo, H. H. Shyu, S. S. Wang, T. C.
Description	Country affiliation: Taiwan Author Affiliation: Kuo HH ( Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan.)
Abstract	Propoxur is among the most popular insect control agents in subtropical countries such as Taiwan. As a member of the N-methylcarbamate insecticide group, propoxur is notorious for its potential for conversion into highly genotoxic N-nitroso derivatives. Due to the fact that the stomach has been identified as the major target for N-nitroso N-methylcarbamates, this investigation used a human gastric cell line, SC-M1, in order to obtain results pertinent to the authentic adverse effects of this compound on human health. This report reveals that at dose levels inhibiting < or = 10% cell growth, a 2-h pulsed treatment of N-nitroso propoxur induced significant amounts of DNA damage. Most of the damaged DNA was repaired within 24 h after treatment removal, such that an outcome with a significant induction of chromosomal aberrations was not observed. Gene mutations and anchorage independence, on the other hand, were significantly induced by this same treatment. In conclusion, exposure to low doses of N-nitroso propoxur is not cytotoxic nor clastogenic, nevertheless, has the potential to increase genetic instability and, possibly as a result, to enhance the malignant potential of treated cells. We suggest that although the damaged DNA was repaired during the transient G2/M arrest period, it was probably not done in an appropriate way which would preserve the original genetic stability.
File Format	HTM / HTML
ISSN	02786915
Issue Number	5
Volume Number	46
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2008-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Mutagens Toxicity Propoxur Analogs & Derivatives Stomach Metabolism Aged Apoptosis Drug Effects Radiation Effects Cell Cycle Cell Division Cell Line, Tumor Chromosome Aberrations Comet Assay Dna Damage Flow Cytometry Histones Biosynthesis Genetics Humans Hypoxanthine Phosphoribosyltransferase Insecticides Kinetics Male Mutagenicity Tests Cytology Ultraviolet Rays Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Patulin: Mechanism of genotoxicity.

Retinyl palmitate is non-genotoxic in Chinese hamster ovary cells in the dark or after pre-irradiation or simultaneous irradiation with UV light.

Genotoxicity evaluation of dimethoate to experimental mice by micronucleus, chromosome aberration tests, and comet assay.

Preface: hazard identification.

Assessment of nicotine-induced DNA damage in a genotoxicological test battery.

The absence of genotoxicity of sucralose.

Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice.

H2AX phosphorylation as a genotoxicity endpoint.

Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies.

Genotoxicity of low dose N-nitroso propoxur to human gastric cells.

Similar Documents

Patulin: Mechanism of genotoxicity.

Retinyl palmitate is non-genotoxic in Chinese hamster ovary cells in the dark or after pre-irradiation or simultaneous irradiation with UV light.

Genotoxicity evaluation of dimethoate to experimental mice by micronucleus, chromosome aberration tests, and comet assay.

Preface: hazard identification.

Assessment of nicotine-induced DNA damage in a genotoxicological test battery.

The absence of genotoxicity of sucralose.

Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice.

H2AX phosphorylation as a genotoxicity endpoint.

Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies.

Genotoxicity of low dose N-nitroso propoxur to human gastric cells.