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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gupta, V. Saggu, S. Tulsawani, R. K. Sawhney, R. C. Kumar, R. |
| Description | Country affiliation: India Author Affiliation: Gupta V ( Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Sciences (DIPAS), Timarpur, Delhi, India. vanitagupta06@gmail.com) |
| Abstract | To examine the dose dependent adaptogenic activity aqueous extract of Rhodiola imbricata root was orally administered in rats at different doses, 30 min prior to cold (5 degrees C)-hypoxia (428 mm Hg)-restraint (C-H-R) exposure. The maximal effective adaptogenic dose of the extract was 100 mg/kg body weight. The acute and sub-acute toxicity of the extract was also studied in rats. Sub-acute toxicity studies included administration of single oral dose of 1 g/kg and 2 g/kg of extract once daily for 14 days and maximal effective single oral dose of 100 mg/kg once daily for 30 days. At the end of each treatment period the biochemical parameters related to liver function, kidney function, lipids (triglycerides, cholesterol) and hematological parameters were estimated in serum and blood. Biochemical and hematological analysis showed no significant changes in any of the parameters examined in treated group's animal, in comparison to control animals. No significant change was observed in organ weight/body weight ratios, of any organ studied in comparison to control rats. The oral LD(50) of the extract was observed to be >10 g/kg, indicating an adequate margin of safety. No histopathological changes were observed in the vital organs studied of the treated animals. These results suggest that aqueous extract of R. imbricata root possess potent adaptogenic activity with no acute and sub-acute toxicity. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 5 |
| Volume Number | 46 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Rhodiola Toxicity Alanine Transaminase Blood Alkaline Phosphatase Animals Aspartate Aminotransferases Bilirubin Metabolism Blood Glucose Blood Proteins Analysis Chromatography, High Pressure Liquid Cold Temperature Dose-response Relationship, Drug Anoxia Physiopathology L-lactate Dehydrogenase Lethal Dose 50 Liver Function Tests Male Phenols Plant Extracts Pharmacology Plants Chemistry Rats Rats, Sprague-dawley Restraint, Physical Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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