NDLI: Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice.

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Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zourgui, Lazhar Golli, Emna El Bouaziz, Chayma Bacha, Hassen Hassen, Wafa
Description	Country affiliation: Tunisia Author Affiliation: Zourgui L ( Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa, Tunisia.)
Abstract	Zearalenone (ZEN) is one of the most widely distributed fusarial mycotoxins which is encountered at high incidence in many foodstuffs. ZEN was associated with different reproductive disorders in animals. Several in vivo studies have shown that ZEN is hepatotoxic, haematotoxic and causes several alterations of immunological parameters. Furthermore, evidence of its cytotoxicity and genotoxicity has recently emerged from several reports. The aim of the current study was (i) to find out whether oxidative stress could be relevant for ZEN induced toxicity in vivo using Balb/c mice and (ii) to evaluate the safety and efficacy of cactus cladodes Opuntia ficus to prevent the deleterious effects of ZEN. To this end, the effect of a single dose of ZEN (40 mg/kg b.w.) alone and with extract of cactus cladodes (25, 50 and 100 mg/kg b.w.) on the induction of oxidative stress was monitored in kidney and liver by measuring the MDA level, the protein carbonyls generation, the catalase activity and the expression of the heat shock proteins (Hsp). Our results clearly showed that ZEN induced significant alterations in all tested oxidative stress markers. Oxidative damage seems to be a key determinant of ZEN induced toxicity in both liver and kidney of Balb/c mice. The combined treatment of ZEN with the lowest tested dose of cactus extracts (25 mg/kg b.w.) showed a total reduction of ZEN induced oxidative damage for all tested markers. It could be concluded that cactus cladodes extract was effective in the protection against ZEN hazards. This could be relevant, particularly with the emergent demand for natural products which may counteract the detrimental effects of oxidative stress and therefore prevent multiple human diseases.
File Format	HTM / HTML
ISSN	02786915
Issue Number	5
Volume Number	46
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2008-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Opuntia Chemistry Oxidative Stress Drug Effects Zearalenone Antagonists & Inhibitors Toxicity Animals Catalase Metabolism Hsp70 Heat-shock Proteins Heat-shock Proteins Immunochemistry Kidney Enzymology Lipid Peroxidation Liver Malondialdehyde Mice Mice, Inbred Balb C Plant Extracts Pharmacology Protein Carbonylation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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Protective effect of Crocin against zearalenone-induced oxidative stress in liver and kidney of Balb/c mice.

Bone Mineral Density, Mechanical, Microstructural Properties and Mineral Content of the Femur in Growing Rats Fed with Cactus Opuntia ficus indica (L.) Mill. (Cactaceae) Cladodes as Calcium Source in Diet

Accumulation and export of nutrients in cactus pear cladodes (Opuntia ficus-indica) under different managements in the Brazilian Semiarid

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Preservation of fresh edible cactus stems (Opuntia ficus indica Mill.) by modified atmosphere packaging

Edible Coatings from Opuntia ficus-indica Cladodes Alongside Chitosan on Quality and Antioxidants in Cherries during Storage

The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice.

Micromorphology of cactus-pear (Opuntia ficus-indica (L.) Mill) cladodes based on scanning microscopies.

Evaluation of Cactus Pear (Opuntia ficus-indica) as Forage in a High Concentrate Total Mixed Ration on Finishing Lambs

Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice.

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Protective effect of Crocin against zearalenone-induced oxidative stress in liver and kidney of Balb/c mice.

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Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice.