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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Piao, Xiang-Lan Cho, Eun Jung Jang, Moon Hee |
| Description | Country affiliation: China Author Affiliation: Piao XL ( Chinese Minority Traditional Medicine Center, College of Life and Environment Sciences, Central University for Nationalities, Beijing, China.) |
| Abstract | The various reactions of peroxynitrite (ONOO(-)) with enzymes, macromolecules and lipids, have been shown to influence cellular functions and may be involved in the pathogenesis of various diseases. Therefore, targeting ONOO(-)-induced cytotoxicity is now accepted as a viable strategy to alleviate disease signs in numerous diseases. There is a growing interest in the antioxidant characteristics and use of dietary flavonoids in the management of ONOO(-)-related diseases. Baicalein, a major bioactive flavonoid constituent of Scutellaria baicalensis Georgi, possesses a multitude of pharmacological activities that have been associated with its antioxidant effects. In this study, we have investigated the ONOO(-) scavenging ability of baicalein and its protective effect on ONOO(-)-induced cell death in cultured LLC-PK(1) cells. Baicalein was able to scavenge ONOO(-) in a concentration-dependent manner, which was comparable to penicillamine. In addition, baicalein at the concentration range of 10-50 microM increased cell viability and decreased LDH leakage in 3-morpholinosydnonimine (SIN-1)-treated cells, reflecting its prevention of ONOO(-)-induced cytotoxicity. These results suggest that the protective effects of baicalein can be explained with respect to its ability to scavenge ONOO(-) and may be useful as a possible therapeutic strategy for the treatment of involved diseases. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 5 |
| Volume Number | 46 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Antioxidants Pharmacology Flavanones Peroxynitrous Acid Antagonists & Inhibitors Toxicity Animals Cell Survival Drug Effects Enzyme Inhibitors Free Radical Scavengers L-lactate Dehydrogenase Metabolism Llc-pk1 Cells Molsidomine Analogs & Derivatives Swine Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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