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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Delgado-Andrade, Cristina Seiquer, Isabel Navarro, M. Pilar Morales, Francisco J. |
| Description | Country affiliation: Spain Author Affiliation: Delgado-Andrade C ( Unidad de Nutrición, Estación Experimental del Zaidín (CSIC), Camino del Jueves, Granada, Spain. cdelgado@eez.csic.es) |
| Abstract | The transport and availability of hydroxymethylfurfural (HMF), an intermediary product of the Maillard reaction, was investigated in the Caco-2 cell line after in vitro gastrointestinal digestion. The study was carried out at two levels; (a) an HMF-spiked culture medium, and (b) digested commercial breakfast cereals (BC). In both assays, the higher the amount of HMF offered to the cells, the higher the absolute value of transported HMF. However, HMF availability and transport are not directly proportional to the initial HMF content since HMF is partly retained in the non-soluble fraction after digestion. In addition, HMF is degraded to some extent during the gastrointestinal digestion of both HMF-spiked cell medium and BC. Average HMF availability from three commercial breakfast cereals was 9.1% (4.98-12.99%). Variations in HMF availability may be related to the particular composition of each BC, where fibre could play an important role. On the other hand, possible metabolization into the cell should also be considered. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 5 |
| Volume Number | 46 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Cereals Chemistry Furaldehyde Analogs & Derivatives Biological Transport, Active Caco-2 Cells Chromatography, High Pressure Liquid Culture Media Metabolism Humans Hydrolysis Proteins Trypsin Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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