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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jun, Hee-jin Lee, Kwang-Geun Lee, Yun-Kyung Woo, Gun-Jo Park, Young Sig Lee, Sung-Joon |
| Description | Author Affiliation: Jun HJ ( Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, Republic of Korea.) |
| Abstract | Furan is a colorless, volatile compound that is found in heat-treated foods, such as canned and jarred foods, at levels up to 100 ppb. When animals ingest high doses, furan metabolites, such as cis-2-butene-1,4-dial, cause severe hepatotoxicity and carcinogenicity. However, the levels and effects of furan on humans are not known. Therefore, we measured urinary furan in 100 healthy individuals consumed normal diet (49 men, 51 women) using solid phase micro-extraction-gas chromatography-mass spectrometry (SPME-GCMS). Urinary furan was detected in 56 subjects (31 males, 25 females) and ranged up to 3.14 ppb. In individuals with detectable urinary furan, the level of gamma-glutamyltranspeptidase (gamma-GT), a marker for liver damage, was strongly correlated with the urinary furan concentration (r=0.56, p<0.0001). Linear regression analysis indicated that the urinary furan level was significantly associated with gamma-GT in both univariate (p<0.0001) and multiple (p=0.0001) models including age, sex, body weight, and blood pressure as covariates. To our knowledge, this is the first study to measure detectable levels of furan in human urine. These levels of urinary furan, which may be dietary origin, could be hepatotoxic in humans; therefore; the metabolic fates and potential toxicity of dietary furan in humans should be investigated further. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 5 |
| Volume Number | 46 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Furans Urine Gamma-glutamyltransferase Blood Adult Aged Aging Physiology Biological Markers Blood Chemical Analysis Body Weight Calibration Female Toxicity Gas Chromatography-mass Spectrometry Humans Linear Models Liver Enzymology Male Middle Aged Sex Characteristics Solid Phase Microextraction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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