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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Yuhong Liu, Yuguo Jiang, Haiqiang Xu, Lingchuan Cheng, Yanna Wang, Peng George Wang, Fengshan |
| Description | Author Affiliation: Liu Y ( Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China); Liu Y ( Department of Pharmacy, Shandong Tumor Hospital, Jinan 250117, China.); Jiang H ( School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.); Xu L ( School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.); Cheng Y ( Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.); Wang PG ( National Glycoengineering Research Center, Shandong University, Jinan 250012, China.); Wang F ( Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China) |
| Abstract | Two sulfated derivatives (PRP-S1 and PRP-S2) of a ß-glucan from Phellinus ribis with different degrees of substitution were obtained by chlorosulfonic acid method. The derivatives could block formation of new vessels in zebrafish and inhibit the proliferation of human umbilical vein endothelial cells (HUVECs). The two sulfated derivatives had remarkably high antitumor activities in vivo (in BALB/c mice inoculated with H22 hepatocellular carcinoma) as well as in vitro (against human ovary cancer SKOV-3 cells), without producing any overt signs of general toxicity. The results of immunohistochemistry assay indicated that the derivatives significantly reduced the average number of microvessel density (MVD) and inhibited the expression of vascular endothelial growth factor (VEGF) in tumor. Thus, these derivatives exhibit pronounced antiangiogenic and antitumoral properties. Except for cytotoxic effects on tumor cells, it is reasonable to expect that the antitumoral effects of PRP-S1 and PRP-S2 are mediated via their antiangiogenic properties. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 106 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Angiogenesis Inhibitors Pharmacology Antineoplastic Agents Basidiomycota Metabolism Glucans Neovascularization, Pathologic Prevention & Control Beta-glucans Chemistry Animals Growth & Development Carbohydrate Sequence Carcinoma, Hepatocellular Blood Supply Drug Therapy Pathology Cell Proliferation Drug Effects Cells, Cultured Female Human Umbilical Vein Endothelial Cells Humans Immunoenzyme Techniques Liver Neoplasms Mice Mice, Inbred Balb C Molecular Sequence Data Ovarian Neoplasms Xenograft Model Antitumor Assays Zebrafish Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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