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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Samanta, Himadri Sekhar Ray, Samit Kumar |
| Description | Country affiliation: India Author Affiliation: Samanta HS ( Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.); Ray SK ( Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India. Electronic address: samitcu2@yahoo.co.in.) |
| Abstract | Several composite hydrogels were synthesized by free radical crosslink copolymerization of acrylic acid (AA) and N' methylene bis-acrylamide (MBA) in the presence of chitosan (CS). During polymerization CS was incorporated in situ in the crosslinked polyacrylic acid gel to produce composite hydrogels. The structure and properties of the hydrogels were characterized by FTIR, (13)C NMR, DTA-TGA, XRD, swelling and diffusion characteristic and also network parameters. The loading and the in vitro release behaviours of theophylline and tinidazole model drugs were studied with these hydrogels. The wt% of CS and MBA and pH of the medium was found to strongly influence the drug release behaviour of the gels. Accordingly, the release rate of these two drugs was much faster at pH of 7.6 than at pH 1.5. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 106 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Acrylates Chemistry Chitosan Delayed-action Preparations Drug Carriers Hydrogels Administration & Dosage Theophylline Tinidazole Alkylating Agents Bronchodilator Agents Calorimetry, Differential Scanning Diffusion Hydrogen-ion Concentration Magnetic Resonance Spectroscopy Spectroscopy, Fourier Transform Infrared X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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