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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Yuhong Liu, Chunhui Jiang, Haiqiang Zhou, Honglei Li, Pingli Wang, Fengshan |
| Description | Author Affiliation: Liu Y ( School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China); Liu C ( Institute of Biochemical and Biotechnological Drug, Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.); Jiang H ( School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.); Zhou H ( School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.); Li P ( Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, China.); Wang F ( Institute of Biochemical and Biotechnological Drug, Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: fswang@sdu.edu.cn.) |
| Abstract | A new polysaccharide named PRG was isolated from the fruiting bodies of Phellinus ribis by hot water extraction, ethanol precipitation, anion-exchange and gel-filtration chromatography. PRG was homogeneous, with a molecular weight of 5.16 × 10(3)Da, as determined by high-performance size-exclusion chromatography-multiangle laser light scattering analysis. Its structural characteristics were investigated and elucidated by methylation analysis, partial acid hydrolysis, gas-liquid chromatography mass spectrometry, Fourier transform infrared and nuclear magnetic resonance spectroscopy. Based on obtained data, PRG was found to be a ß-d-glucan containing a (1 â 3)-linked backbone, with a branch of two (1 â 6)-linked and one terminal glucoses substituting at the C-6 position every three residues, along the main chain. PRG exhibited neurotrophic activity, which significantly promoted the neurite outgrowth of the nerve growth factor-stimulated PC12 cells, suggesting that it might be a potential candidate for the treatment of neurodegenerative diseases. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 127 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Basidiomycota Chemistry Fungal Polysaccharides Neurites Drug Effects Animals Carbohydrate Sequence Pharmacology Glucose Analysis Molecular Sequence Data Pc12 Cells Rats Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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