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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Silva, Nuno H. C. S. Rodrigues, Artur Filipe Almeida, Isabel F. Costa, Paulo C. Rosado, Catarina Neto, Carlos Pascoal Silvestre, Armando J. D. Freire, Carmen S. R. |
| Description | Country affiliation: Portugal Author Affiliation: Silva NH ( CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Rodrigues AF ( CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Almeida IF ( Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Portugal.); Costa PC ( Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Portugal.); Rosado C ( CBIOS, UDE - Experimental Dermatology Unit, Universidade Lusófona, Campo Grande 376, 1749-024 Lisbon, Portugal.); Neto CP ( CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Silvestre AJ ( CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Freire CS ( CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: cfreire@ua.pt.) |
| Abstract | Bacterial cellulose (BC) membranes were explored as novel nanostructured transdermal delivery systems for diclofenac sodium salt (a typical non-steroidal anti-inflammatory drug). Diclofenac sodium salt loaded BC membranes were prepared through a simple methodology, using glycerol as plasticizer, and characterized in terms of structure, morphology and swelling behavior. The membranes were very homogeneous, quite flexible and presented a considerably higher swelling behavior when compared with pure BC. In vitro diffusion studies with Franz cells, were conducted using human epidermal membranes, and showed that the incorporation of diclofenac in BC membranes provided similar permeation rates to those obtained with commercial patches and substantially lower than those observed with a commercial gel. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes clearly indicates the enormous potentialities of using BC membranes for transdermal administration of diclofenac. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 106 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Anti-inflammatory Agents, Non-steroidal Administration & Dosage Cellulose Diclofenac Membranes, Artificial Transdermal Patch Bacteria Ultrastructure Epidermis Metabolism Gels Humans In Vitro Techniques Microscopy, Electron, Scanning Nanofibers Skin Absorption Solubility Spectroscopy, Fourier Transform Infrared Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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