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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Panagos, Charalampos G. Thomson, Derek Moss, Claire Bavington, Charles D. Olafsson, Halldór G. Uhrín, Dusan |
| Description | Author Affiliation: Panagos CG ( EaStCHEM School of Chemistry, Joseph Black Building, The King's Buildings, Edinburgh EH9 3JJ, UK. Electronic address: cpanagos@staffmail.ed.ac.uk.); Thomson D ( GlycoMar Ltd, European Centre for Marine Biotechnology, Oban, Scotland PA37 1QA, UK. Electronic address: derek@glycomar.com.); Moss C ( GlycoMar Ltd, European Centre for Marine Biotechnology, Oban, Scotland PA37 1QA, UK. Electronic address: claire@glycomar.com.); Bavington CD ( GlycoMar Ltd, European Centre for Marine Biotechnology, Oban, Scotland PA37 1QA, UK. Electronic address: charlie@glycomar.com.); Olafsson HG ( Biopol, Einbúastíg 2, 545 Skagaströnd, Iceland. Electronic address: halldor@biopol.is.); Uhrín D ( EaStCHEM School of Chemistry, Joseph Black Building, The King's Buildings, Edinburgh EH9 3JJ, UK. Electronic address: dusan.uhrin@ed.ac.uk.) |
| Abstract | The lumpsucker, Cyclopterus lumpus, a cottoid teleost fish found in the cold waters of the North Atlantic, and North Pacific, was identified as a possible source of GAGs. The GAGs present in the C. lumpus dorsal hump and body wall tissue were isolated and purified. Two fractions were analysed by NMR and their GAG structures determined as hyaluronic acid and CS/DS chains. The latter fraction contained GlcA (65% of the total uronic acids) and IdoA (the remaining 35%). All uronic acid residues were unsulfated, whilst 86% of the GalNAc was 4-sulfated and 14% was 6-sulfated. The presence of GlcA-GalNAc4S, IdoA-GalNAc4S and GlcA-GalNAc6S disaccharide fragments was confirmed. The isolated GAGs obtained from each tissue were biochemically characterised. The lumpsucker offers a high yield source of GAGs, which compares favourably with other sources such as shark cartilage. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 106 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Chondroitin Sulfates Chemistry Dermatan Sulfate Analogs & Derivatives Fishes Metabolism Hyaluronic Acid Polymers Animals Isolation & Purification Magnetic Resonance Spectroscopy Oxidation-reduction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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