NDLI: The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.

Please wait, while we are loading the content...

Probiotic intervention improves gingival status and influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults

The subgingival microbiomes in periodontitis and health of individuals with rheumatoid arthritis and at risk of developing rheumatoid arthritis

Bacterial Communities within Gingival Tissues from Periodontal Lesions Compared with Subgingival Plaque

Microbiome associated with peri-implantitis versus periodontal health in individuals with a history of periodontal disease

Clinical oral microbiology and antimicrobial susceptibility – does it matter?

Prescription of antibiotics in dentistry - a report from the Swedish STRAMA work

Bacteriophages targeting Enterococcus faecalis strains - a potential new root canal therapy

Functional isoeugenol-modified nanogel coatings for implants

Antibacterial effects of bio-inspired nanostructured materials

Interactions of periodontal pathogens with megakaryocytic cells and platelets

Role of Porphyromonas gingivalis’s peptidylarginine deiminase in multispecies biofilm formation and bacterial adherence to host cells

Effects of statins on multispecies oral biofilm

Determination of MIC of amoxicillin among clinical strains of Aggregatibacter actinomycetemcomitans from various geographic regions endorse the continuous use of this drug for treatment of periodontitis

Shotgun proteomic analysis of Anaeroglobus geminatus

The microbiome of oral leukoplakia shows enrichment in Fusobacteria and Rothia species

The oral mucosal microbiome in children with Crohn’s disease exhibits reduced biodiversity compared to healthy children, revealed by 16s profiling

Site-specific plaque pH before and after short-term use of 1.5% Arginine dentifrice in caries-free and caries-active individuals

Herpes simplex virus type 1 and 2 in mucocutaneous infections

The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains

Generation and characterisation of Porphyromonas gingivalis mutant lacking peptidylarginine deiminase activity

Modulation of neutrophil chemotaxis by Aggregatibacter actinomycetemcomitans leukotoxin

Comparison of paperpoint and curette sampling of subgingival microbiome composition as analyzed by 16S rRNA gene amplicon sequencing

Multilocus sequence typing (MLST) of JP2 genotype isolates of Aggregatibacter actinomycetemcomitans collected from carriers of African and non-African origin

Communication at the host-pathogen interface

The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.

Investigation of the prevalence of Tn916/Tn916-like elements in oral streptococci

Modeling the development of proteolytic phenotypes in multi-species oral biofilms

The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.

Content Provider	Taylor & Francis Online
Author	Bolstad, Anne Isine Al-Zubaydi, Sundus Saad Dabija-Wolter, Gabriela Mohammed, Marwan Mansoor Ali
Abstract	Background: Antibiotic resistance has become life-threatening. A combination of metronidazole and amoxicillin is commonly used as adjunct to periodontal therapy. The aim of this study was to utilize an in vitro biofilm model to test the effect of replacing the broad-spectrum amoxicillin with penicillin V in the combination with metronidazole.Methods: An in vitro biofilm model, consisting of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum was developed. Biofilms were exposed to chlorhexidine digluconate (CHX) 0.2%, as positive control, and either to metronidazole/amoxicillin or metronidazole/penicillin V in two different concentrations. Statistical significance was achieved if p < 0.05 with paired t-test.Results: There was no growth of any bacterial species after 2h exposure to 0.2% CHX. Together, the two combinations of antibiotics were effective against F. nucleatum and P. gingivalis, but less effective against A. actinomycetemcomitans. No significant difference was found between the two combinations of antibiotics to combat A. actinomycetemcomitans neither in high (p = 0.95) nor in low concentration (p = 0.17).Conclusion: A combination of metronidazole with penicillin V had similar inhibiting effect as metronidazole combined with amoxicillin on an in vitro three-species biofilm model. Use of a narrow spectrum antibiotic may be indicated in combination with metronidazole.
File Format	PDF HTM / HTML
ISSN	20002297
DOI	10.1080/20002297.2017.1325270
Journal	Journal of Oral Microbiology
Volume Number	9
Issue Number	sup1
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-06-01
Access Restriction	Open
Content Type	Text
Subject	Microbiology (medical) Dentistry Infectious Diseases 3500/3501

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on periodontal pathogens in an in vitro biofilm model

Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model

Metatranscriptomic analysis of an in vitro biofilm model reveals strain-specific interactions among multiple bacterial species

Effect of azithromycin on a red complex polymicrobial biofilm

Association of antimicrobial perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in colorectal surgery

Prophylaxis with Amoxicillin or Sulfisoxazole for Otitis Media: Effect on the Recovery of Penicillin-Resistant Bacteria from Children

Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci.

Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin Plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis

Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm

The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.

Similar Documents

The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on periodontal pathogens in an in vitro biofilm model

Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model

Metatranscriptomic analysis of an in vitro biofilm model reveals strain-specific interactions among multiple bacterial species

Effect of azithromycin on a red complex polymicrobial biofilm

Association of antimicrobial perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in colorectal surgery

Prophylaxis with Amoxicillin or Sulfisoxazole for Otitis Media: Effect on the Recovery of Penicillin-Resistant Bacteria from Children

Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci.

Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin Plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis

Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm

The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.