NDLI: Dysbiosis and inflammation in periodontitis: synergism and implications for treatment

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Volume 11, 2019

Volume 10, 2018

Volume: 9 Issue: 2

Oral Microbiology – progress, myths and evidence

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The bacteriome and mycobiome associated with oral squamous cell carcinoma: metagenomic analysis of samples from Yemeni and Sri Lankan cohorts

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The metatranscriptomes of root caries and sound root surface biofilms

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The Endodontic Microbial Biofilms as An Extension of Dental Plaque, a general hypothesis

Dysbiosis and inflammation in periodontitis: synergism and implications for treatment

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Investigation of the prevalence of Tn916/Tn916-like elements in oral streptococci

Modeling the development of proteolytic phenotypes in multi-species oral biofilms

Volume: 9 Issue: 1

Dysbiosis and inflammation in periodontitis: synergism and implications for treatment

Content Provider	Taylor & Francis Online
Author	Hajishengallis, George
Abstract	Recent advances from microbiome and host response mechanistic studies indicate that periodontitis is not a bacterial infection in the classical sense but rather results from dysbiosis owing to a breakdown in host-microbe homeostasis. Accordingly, periodontitis is induced in susceptible hosts by a polymicrobial community, in which different members have distinct roles that converge synergistically to enhance colonization, nutrient procurement and persistence in an inflammatory environment. Keystone pathogens – the colonization of which is facilitated by accessory pathogens – initially subvert the host response leading to the emergence of a dysbiotic microbiota, in which pathobionts overactivate the inflammatory response and cause periodontal tissue destruction. Inflammation and dysbiosis positively reinforce each other because inflammatory tissue breakdown products are used as nutrients by the dysbiotic microbiota, thereby contributing to its persistence and chronic inflammation. These concepts have important implications for novel therapeutic approaches, including strategies for microbial community manipulation and targeted modulation of the host response to limit destructive inflammation and reverse the microbial immune subversive tactics that fuel dysbiosis.
File Format	PDF HTM / HTML
ISSN	20002297
DOI	10.1080/20002297.2017.1325198
Journal	Journal of Oral Microbiology
Volume Number	9
Issue Number	sup1
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-05-25
Access Restriction	Open
Content Type	Text
Subject	Microbiology (medical) Dentistry Infectious Diseases 3500/3501

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