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Bacteriophages targeting Enterococcus faecalis strains - a potential new root canal therapy

Content Provider	Taylor & Francis Online
Author	Zubidi, Mohammed Al
Abstract	The most common isolated species from recalcitrant endodontic infections is Enterococcus faecalis, a gram positive multiply drug-resistant and environmentally stable bacterium. As a potential route to a biological solution to E. faecalis root-canal infection we aimed to isolate, characterise and test in vitro a range of lytic bacteriophages targeted against E. faecalis isolates from oral endodontic infections obtained from labs across Europe.Five bacteriophages were isolated from concentrated waste water named (SHEF2,4,5,6,7) that belong to the Siphoviridae family. They are specific to E. faecalis with genome sizes ranging from 39-43kb. Full chromosome sequences of SHEF2,4 and 5 alongside biological evidence revealed that they are lytic bacteriophages which place them as suitable candidate for therapy. We tested the ability of these phages to eradicate biofilm from abiotic surfaces and a novel cross-sectional tooth model while also showing that they are able to rescue Zebrafish embryos from E. faecalis systemic clinical strain infection. Finally, we established that the extracellular exopolysaccharide of E. faecalis was the bacterial docking target of these phages during the initial stages of phage infection. We suggest that these or other bacteriophages might be novel adjuncts to current endodontic therapy to eradicate recalcitrant biofilm and antibiotic resistant E. faecalis.
File Format	PDF HTM / HTML
ISSN	20002297
DOI	10.1080/20002297.2017.1325237
Journal	Journal of Oral Microbiology
Volume Number	9
Issue Number	sup1
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-07-10
Access Restriction	Open
Content Type	Text
Subject	Microbiology (medical) Dentistry Infectious Diseases 3500/3501

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