NDLI: The bacteriome and mycobiome associated with oral squamous cell carcinoma: metagenomic analysis of samples from Yemeni and Sri Lankan cohorts

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The bacteriome and mycobiome associated with oral squamous cell carcinoma: metagenomic analysis of samples from Yemeni and Sri Lankan cohorts

Content Provider	Taylor & Francis Online
Author	Ulett, Glen Nasher, Akram Perera, Manosha Idris, Ali Mohamed Maryoud, Mohamed Ipe, Deepak Speicher, David Chen, Tsute Homeida, Husham Johnson, Newell Al-hebshi, Nezar Perera, Irosha
Abstract	There is increasing interest in the possible role of the oral microbiome in oral squamous cell carcinoma (OSSC). However, studies on the possible association between the oral bacteriome and OSCC remain inconclusive, while the potential role of the “mycobiome” in oral carcinogenesis has never been explored. I hereby present results from our recent studies on the bacteriome and mycobiome associated with OSCC based on analysis of samples from Yemeni and Sri Lankan cohorts. Tissue biopsies were obtained from the cases while deep buccal swabs or fibro-epithelial polyps were collected from the controls. Sequencing of the bacterial V1-V3 region of the 16S rRNA gene and the fungal ITS2 region using Illumina’s 2x300 bp chemistry was employed to study the bacteriome and mycobiome, respectively. Merged reads were classified to species level using a BLASTN-algorithm. Downstream analyses were performed using QIIME, PICRUSt, and LEfSe. Fusobacterium nucleatum subsp. polymorphum, Pseudomonas aeruginosa, Prevotella and Campylobacter spp. were more abundant in OSCC samples while Streptococcus mitis and Rothia spp. were overrepresented in the controls. Functionally, inflammatory bacterial attributes including bacterial mobility, flagellar assembly, bacterial chemotaxis and LPS synthesis were enriched in the tumors. Mycobiome analysis revealed a dysbiotic fungal community dominated by C. albicans in association with OSCC.
File Format	PDF HTM / HTML
ISSN	20002297
DOI	10.1080/20002297.2017.1325188
Journal	Journal of Oral Microbiology
Volume Number	9
Issue Number	sup1
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-06-09
Access Restriction	Open
Content Type	Text
Subject	Microbiology (medical) Dentistry Infectious Diseases 3500/3501

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