NDLI: P1.11 Central Systolic Augmentation Indexes and Urinary Sodium in a White Population

Content Provider	Springer Nature : BioMed Central
Author	Liu, Y. P. Thijs, L. Kuznetsova, T. Gu, Y. M. Asayama, K. Stolarz-Skrzypek, K. Jin, Y. Verhamme, P. Struijker-Boudier, H. Staessen, J. A.
Abstract	Background The association between cardiovascular health and salt intake remains controversial. Methods In 630 participants (mean age 40.6 years; 51% women), randomly recruited from F. alemish population, we measured sodium and creatinine in 24 hour urine samples at baseline and follow-up (median, 9.7 years) and the carotid and aortic augmentation indexes (AI) standardized to heart rate at follow-up only. Results The carotid AI (130.2% vs 113.7%) and aortic AI (145.7 vs 127.4) were higher (P<0.0001) in women than men and increased with age (10.1% and 8.5% per 10 years). From baseline to follow-up, the urinary sodium concentration decreased (117.1 vs 105.2 mmol/L; P<0.0001), whereas 24 hour urinary sodium did not change (166.5 vs 171.5 mmol; P = 0.12). In multivariable-adjusted longitudinal analyses, a 40 mmol/L (~1 SD) increase in the urinary sodium concentration at baseline was independently and inversely associated with the carotid AI (effect size, 1.38±0.66%; P = 0.038) and aortic AI (1.54±0.72%; P = 0.019). In cross-sectional analyses of follow-up data, these estimates were 1.26±0.70% (P = 0.07) and 1.52±0.76% (P = 0.045), respectively. In the longitudinal and cross-sectional analyses, the carotid and aortic AIs were unrelated to the 24 hour urinary excretion of sodium (P≥0.43). Conclusions Our study showed an inverse association between the AIs in the central arteries and the urinary sodium concentration, but not sodium excretion. Vasodilatation of the afferent renal arterioles in response to higher sodium concentration is mediated via the connecting tubule glomerular feedback mechanism; this might move reflection sites in the renal arteries more distally and thereby explain our observations.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2012.09.048.pdf
Ending Page	154
Page Count	1
Starting Page	154
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2012.09.048
Journal	Artery Research
Issue Number	4
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2012-11-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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