NDLI: P3.08: Nitroglycerin Effect on Aortal Augmentation and Central Augmentation Index

Content Provider	Springer Nature : BioMed Central
Author	Berzina, M. Krallisa, A. Latkovskis, G. Zabunova, M. Mintale, I. Erglis, A.
Abstract	Background Nitroglycerin (NG) reduces the systolic blood pressure, pulse pressure and augmentation index. The aim of our study was to evaluate the effect of NG on aortal augmentation (AA) and central augmentation index (CAI) in patients with different significance of the angiographically proved coronary artery disease (CAD). Methods The group of 66 patients referred for scheduled coronary angiography at Paul Stradins Clinical University Hospital Latvian Centre of Cardiology was analyzed. The mean age of patients was 62.8±11.9 years, 48.5% of them were male. The data about case history, cardiovascular risk factors, previous and concomitant therapy were collected. The applanation tonometry with Sphygmocor device, including radial pulse wave analysis (PWA), carotid PWA, carotid-femoral PWV before and after NG, was done. Coronary angiography was done for determination of presence and degree of coronary artery stenoses (CAS). Results Aortal augmentation and central augmentation index before and after nitroglycerin are seen in the Table 1. PWA No CAS CAS<50% CAS 50–70% CAS>70% p value AA before NG, mmHg 12.7± 10.9 17.4 ± 7.2 15.3 ± 6.4 22.0 ± 9.9 0.012 AA after NG, mmHg 4.3 ± 6.4 2.3 ± 8.1 2.6 ±4.7 11.5 ± 9.9 0.003 CAI before NG, % 25.2 ± 16.3 36.0 ± 17.9 28.6 ± 6.8 37.0 ± 10.0 0.019 CAI after NG, % 9.8 ± 15.3 6.3 ± 19.9 4.3 ± 9.7 21.0 ± 15.3 0.014 AA decrease after NG, % 86.0 ± 62.9 80.8 ± 39.0 89.1 ± 25.5 48.4 ±47.8 0.061 CAI decrease after NG, % 89.6 ± 73.9 71.4 ±45.4 87.7 ± 34.2 46.5 ± 38.6 0.055 Table 1 PWA before and after NG test and CAS. Conclusions There is a tendency of less decrease of the aortal augmentation and central augmentation index after the nitroglicerine test in patients with significant CAS. Additive prognostic value of nitroglicerine test should be further explored in future studies.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2011.10.043.pdf
Ending Page	158
Page Count	1
Starting Page	158
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2011.10.043
Journal	Artery Research
Issue Number	4
Volume Number	5
Language	English
Publisher	BioMed Central
Publisher Date	2011-11-29
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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