NDLI: P1.08 Prediction of Cardiovascular Events with Aortic Stiffness in Patients with Erectile Dysfunction

Content Provider	Springer Nature : BioMed Central
Author	Vlachopoulos, C. Ioakeimidis, N. Aznaouridis, K. Aggelis, A. Terentes-Printzios, D. Aggelakas, A. Abdelrasoul, M. Synodinos, A. Lazaros, G. Stefanadis, C.
Abstract	Background Erectile dysfunction (ED) confers an independent risk for cardiovascular events and total mortality. Aortic pulse wave velocity (PWV) is an important predictor of cardiovascular events and all-cause mortality. We investigated whether PWV predicts major adverse cardiovascular events (MACE) in patients with ED beyond traditional risk factors. Methods MACE in relation to PWV were analyzed with proportional hazards models in 344 patients (mean age 56 years) without established cardiovascular disease. Results During a mean follow-up of 4.7 years (range 1–8.5), 24/344 participants experienced a MACE. ED population was divided into tertiles according to the PWV values (low tertile <7.6 m/s; middle tertile 7.6–8.8 m/s; high tertile >8.8 m/s). KaplaneMeier survival analysis showed that PWV was associated with MACE and the difference between the tertiles was significant (Mantel log-rank test: 11.161; P = 0.004, figure). Subjects in the highest PWV tertile had a 4-fold higher risk of MACE compared to those in the lowest PWV tertile (adjusted HR 3.97, P = 0.035). A PWV value of 7.81 m/sec was associated with a negative predictive value (ability to “rule out” MACE) of 98.1 %. Addition of PWV to standard risk factors model yielded correct patient reclassification to higher or lower risk category by 27.6% (P = 0.0332) in the whole cohort. Conclusions Higher aortic stiffness is associated with increased risk for a MACE in ED patients without known cardiovascular disease. Aortic PWV improves risk prediction when added to standard risk factors and may represent a valuable biomarker of prediction of cardiovascular disease risk in these patients.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2012.09.045.pdf
Ending Page	153
Page Count	1
Starting Page	153
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2012.09.045
Journal	Artery Research
Issue Number	4
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2012-11-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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P1.08: Prediction of Cardiovascular Events with Aortic Stiffness in Patients with Erectile Dysfunction

Prediction of cardiovascular events with aortic stiffness in patients with erectile dysfunction.

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