NDLI: P1.36 Arterial Stiffness and Markers of Oxidative Stress Haptoglobin and Homocysteine in Never Treated Incident Hypertensive Patients

Content Provider	Springer Nature : BioMed Central
Author	Strandhave, C. Svensson, M. Krarup, H. Christensen, J. H.
Abstract	Introduction Hypertension is a major risk factor for development of cardiovascular disease (CVD). Arterial stiffness is a risk predictor of CVD in this patient group. Oxidative stress has been implicated in the development of arterial stiffness. Haptoglobin (Hp) and homocysteine (Hcy) are well documented markers of oxidative stress. We hypothesized that Hp and Hcy are associated with arterial stiffness in never treated incident hypertensive patients. Methods and Material We examined 125 patients with newly diagnosed never treated hypertension. Patients had 24h ambulatory blood pressure (BP) measurement (Spacelabs Healthcare®, Hertford, UK) performed and were eligible if daytime BP was ≥ 135/85 mmHg. Arterial stiffness expressed as carotid-femoral pulse wave velocity (cfPWV), augmentation index at heart rate 75 (AIx@75), and central systolic blood pressure (cenBP) were measured with the SphygmoCor® device (Atcor Medical®, Sydney, Australia). Hp and Hcy were determined using rate nephelometry (Beckmann IMMAGETM, DK). Results Patient baseline characteristics are shown in the Table. In a univariate correlation Hp showed a weak association with AIx@75 (r=0.16, p=0.04) which in an adjusted regression model remained significant (r2 =0.45, p=0.02). Hp was not associated with cfPWV or cenBP nor was there any association between Hcy and cfPWV, AIx@75, and cenBP. Conclusion Only Hp was associated with arterial stiffness (AIx@75) whereas no other associations were found. Thus, Hcy appear not to be associated with arterial stiffness in hypertension and further studies are warranted to elucidate the role of Hp as a risk marker in hypertension.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2012.09.073.pdf
Ending Page	161
Page Count	1
Starting Page	161
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2012.09.073
Journal	Artery Research
Issue Number	4
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2012-11-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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