NDLI: P4.20 Association of a Single Nucleotide Polymorphism in CYP2C8 with Myocardial Infarction in Bulgarian Population

Content Provider	Springer Nature : BioMed Central
Author	Atanasova, G. A. Tzveova, R. T. Tzekova, M. T. Kaneva, R. K. Mitev, V. M.
Abstract	Cytochrome P450 2C8 is a polymorphic enzyme responsible for the biosynthesis of vasoactive substances from arachidonic acid. Inter-individual differences in the action of these substances might be important in the pathogenesis of cardiovascular diseases such as acute myocardial infarction (AMI). In the present study we analyzed the association of a genetic variant in CYP2C8 and the morbidity of AMI in Bulgarian population. The study included 99 AMI patients and 370 control subjects. To determine the genotypes of the samples real time PCR with predesigned TaqMan SNP Genotyping Assays (Applied Biosystem) was used. The rare allele (C) was found in 16% of the affected and 10% of the non affected cases and it showed statistical significance [OR (95% CI): 1.64 (1.00−2.56), P = 0.03]. The TT genotype occurred more often in the control group compared with the patients with AMI [OR (95% CI): 0.58 (0.35−0.96), P = 0.039]. The heterozygous genotype of CYP2C8 was found to be significantly associated with a risk of myocardial infarction [OR (95% CI): 2.25 (1.06−4.75), P = 0.036] in women. Possession of the rare genetic variant of CYP2C8 gene in Bulgarian population is associated with a modestly increased risk of AMI.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2012.09.168.pdf
Ending Page	189
Page Count	2
Starting Page	188
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2012.09.168
Journal	Artery Research
Issue Number	4
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2012-11-17
Access Restriction	Open
Subject Keyword	Medicine Public Health CYP2C8 risk association Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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