NDLI: 3.3 Pressure-Independent Aortic Stiffening Evaluation in Various Hypertensive Rat Models in Vivo, Via Pulsatile Diameter Recording

Content Provider	Springer Nature : BioMed Central
Author	Vayssettes-Courchay, C. Ragonnet, C. Isabelle, M. Vilaine, J. P.
Abstract	We have shown that in addition to compliance and distensibility, the analysis of the arterial distension (pulsatile diameter) via echotracking (ArtLab) provides information to discriminate the pressure-dependent and independent arterial stiffening. In the present study we evaluated these parameters in different hypertensive rat models. Mean, systolic, diastolic and pulse arterial pressure (AP) and the aortic diameter were recorded in 6 groups of pentobarbital anaesthetized rats: 20 week old spontaneously hypertensive rat (SHR), SHR treated with the NOS inhibitor L-NAME 6 mg/ kg/day in drinking water (SHRLN), 50–60 week old SHR, DOCA-salt (uninephrectomized, deoxycorticosterone treated rats) and VDN (VitamineD+-Nicotine treated rats); all were compared to their respective controls: Wistar-Kyoto (WKY) and Wistar normotensive rats. The diameter was comparable in all groups. Except in the DOCA-salt, increased stiffness index and decreased compliance, distensibility and distension were observed, indicating an aortic stiffening. When in each rat AP was decreased acutely by clonidine i.v., reaching the control rat values of AP, stiffness index, compliance and distensibility were more or less restored in SHR>old SHR = SHRLN>VDN; however the diameter distension wave (area under the curve adjusted to heart rate) was restored in SHR, partially in old SHR, but not in SHRLN and VDN (table). These data show, via the analysis of the aortic pulse diameter distension, that in SHRLN and VDN the increase in aortic stiffness is in part pressure-independent and due to arterial wall remodeling. The results are in line with previous structural vascular wall studies.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2012.09.021.pdf
Ending Page	146
Page Count	2
Starting Page	145
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2012.09.021
Journal	Artery Research
Issue Number	4
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2012-11-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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