NDLI: P1.43 Interaction of Hyperalbuminuria, Artherosclerotic Plaques and Elevated Pulse Wave Velocity with Age and Risk Category in Apparently Healthy Subjects

Content Provider	Springer Nature : BioMed Central
Author	Greve, S. V. Blicher, M. Blyme, A. Sehestedt, T. Hansen, T. W. Rasmussen, S. Vishram, J. Ibsen, H. Torp-Pedersen, C. Olsen, M. H.
Abstract	Subclinical vascular damage (SVD) predicts cardiovascular events independently of traditional risk factors in apparently healthy subjects. But information on coexistence and additive prognostic importance in different age and groups are lacking. In 2082 apparently healthy subjects aged 41, 51, 61 and 71 years we estimated cardiovascular risk using SCORE, performed ultrasound of the carotid arteries and measured urine albumin/creatinine ratio (UACR) and pulse wave velocity (PWV) in 1993. The composite endpoint (CEP) of cardiovascular death, non-fatal myocardial infarction and stroke, and hospitalization for ischemic heart disease was recorded until 2006. Between the four age groups and the four SCORE risk groups, the prevalence of hyperalbuminuria (above 90 percentile), atherosclerotic plaques and elevated PWV increased. The prevalence of subjects with one or more SVD increased between the four age groups as well as the four risk groups. Increasing numbers of markers for SVD (0, 1, 2 or 3) was associated with higher incidence of CEP in the three youngest age groups (41+51 years: 4.7, 9.4, 20.8, 50%; 61 years: 7.7, 15.3, 25.9, 35.7%, both P<0.001; 71 years: 21.2, 21.5, 27.9, 43.3%, P=0.08) and in patients with SCORE<10% (SCORE<5%: 4.6, 9.2, 20.6, 60%, P<0.001; 5≤SCORE<10%: 9.8, 18.4, 20.8, 36.8%, P<0.05%; SCORE ≥10%: 25.0, 23.5, 35.4, 42.3%, NS). Concluding that the advantage of combined markers for SVD is doubtful in subjects aged 41 years or SCORE<1% due to low prevalence as well as in subjects aged 71 years or SCORE≥10% due very high prevalence and low additive predictive value.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2012.09.080.pdf
Ending Page	163
Page Count	2
Starting Page	162
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2012.09.080
Journal	Artery Research
Issue Number	4
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2012-11-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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P1.43: Interaction of Hyperalbuminuria, Artherosclerotic Plaques and Elevated Pulse Wave Velocity with Age and Risk Category in Apparently Healthy Subjects

P12.01 Local Carotid Stiffness Versus Carotid-Femoral Pulse Wave Velocity in Normal Subjects and Patients with Risk Factors

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P.079 Pulse Wave Velocity in Subjects with Masked Hypertension and White Coat Hypertension

P1.13 Changes in Pulse Wave Velocity Alone Cannot Predict the Pulse Pressure Increase with Age

P6.11: Retinal Pulse Wave Velocity in Young Normotensive and Mildly Hypertensive Subjects

P2.16 Precision and Reproducibility of Vicorder-Estimated Pulse Wave Velocity in Healthy Volunteers

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P1.43 Interaction of Hyperalbuminuria, Artherosclerotic Plaques and Elevated Pulse Wave Velocity with Age and Risk Category in Apparently Healthy Subjects

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P1.43: Interaction of Hyperalbuminuria, Artherosclerotic Plaques and Elevated Pulse Wave Velocity with Age and Risk Category in Apparently Healthy Subjects

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P1.43 Interaction of Hyperalbuminuria, Artherosclerotic Plaques and Elevated Pulse Wave Velocity with Age and Risk Category in Apparently Healthy Subjects