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Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases
| Content Provider | Semantic Scholar |
|---|---|
| Author | Heinosalo, Taija Saarinen, Niina M. Poutanen, Matti |
| Copyright Year | 2019 |
| Abstract | Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of various human diseases, such as endometriosis and cancers arising from the breast and uterus. Steroid biosynthesis is a multistep enzymatic process proceeding from cholesterol to highly active sex steroids via different intermediates. Human Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) enzyme shows a high capacity to produce the highly active estrogen, estradiol, from a precursor hormone, estrone. However, the enzyme may also play a role in other steps of the steroid biosynthesis pathway. In this article, we have reviewed the literature on HSD17B1, and summarize the role of the enzyme in hormone-dependent diseases in women as evidenced by preclinical studies. |
| Starting Page | 9 |
| Ending Page | 31 |
| Page Count | 23 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.mce.2018.08.004 |
| PubMed reference number | 30149044 |
| Journal | Medline |
| Volume Number | 489 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0303720718302399 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0303720718302399?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.mce.2018.08.004 |
| Journal | Molecular and Cellular Endocrinology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
