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Comparative proteome profiling of breast tumor cell lines by gel electrophoresis and mass spectrometry reveals an epithelial mesenchymal transition associated protein signature

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Molecular BioSystems Vol - 9 Issue - 5

Molecular BioSystems Vol - 9 Issue - 4

Molecular BioSystems Vol - 9 Issue - 3

Molecular BioSystems Vol - 9 Issue - 2

Molecular BioSystems Vol -8

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Comparative proteome profiling of breast tumor cell lines by gel electrophoresis and mass spectrometry reveals an epithelial mesenchymal transition associated protein signature

Content Provider	Royal Society of Chemistry (RSC)
Author	Acierno, Raffaele Maffia, Michele Toto, Claudia Giannelli, Gianluigi Sacchetta, Paolo Simeone, Pasquale Salzet, Michel Vergara, Daniele Tinelli, Andrea Pieragostino, Damiana Boccio, Piero del Alberti, Saverio
Copyright Year	2013
Abstract	The epithelial to mesenchymal transition (EMT) is a cellular program associated with the organ morphogenesis but also with the disease progression. EMT in the cancer field fuels neoplastic progression promoting the resistance to cell death, the resistance to chemotherapy and the acquisition of stem cell properties. Considering the crucial role of EMT in breast cancer metastasis, a better understanding of this process may provide new therapeutic options. Here, by using a proteomic approach we identified a set of proteins differentially expressed between an epithelial and a mesenchymal breast cancer cell line. The protein–protein network of these identified proteins was determined by an in silico analysis highlighting, in the EMT program, the role of proteins involved in cell adhesion, migration, and invasion, together with protein kinases involved in proliferation and survival, with many of these emerging as possible targets of novel biological agents. Finally, the pharmacological inhibition of some of these kinases was able to reverse the mesenchymal phenotype to an epithelial phenotype.
Starting Page	1127
Ending Page	1138
Page Count	12
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	9
Issue Number	6
Journal	Molecular BioSystems
DOI	10.1039/c2mb25401h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Morphogenesis Chemotherapy Phenotype Stem cell Cell adhesion Breast cancer Metastasis Protein Cancer
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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