NDLI: Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (<sup>1</sup>H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC)

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Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (¹H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC)

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Molecular BioSystems Vol - 9 Issue - 5

Molecular BioSystems Vol - 9 Issue - 4

Molecular BioSystems Vol - 9 Issue - 3

Molecular BioSystems Vol - 9 Issue - 2

Molecular BioSystems Vol -8

Molecular BioSystems Vol -7

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Molecular BioSystems Vol -2

Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (¹H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC)

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhao, Tong Cao, Bei Shen, Jianmin Zhang, Xiaoli Zhang, Haixia Xu, Luan Liu, Xiaoyan
Copyright Year	2013
Abstract	Arthus reaction (AR), a type of unconventional immune complex-mediated inflammation, is likely accompanied by alterations in circulating metabolites. Here, a proton nuclear magnetic resonance (1H NMR) spectroscopy method coupled with a rapid resolution liquid chromatography (RRLC) method was developed to evaluate the systemic metabolic consequences of AR and characterize metabolic aberrations. Serum and urine samples from AR rats and normal controls were compared to determine whether there were significant alterations associated with AR. The partial least squares discriminant analysis (PLS-DA) models of metabolomic results demonstrated good intergroup separations between AR rats and normal controls. Multivariate statistical analysis revealed significant alterations in the levels of 34 metabolites, which were termed as the disease-associated biomarkers. Differential metabolites identified from the metabolomic analysis suggested that AR caused dysfunctions of kidney and liver accompanied with changes in widespread metabolic pathways including the tricarboxylic acid (TCA) cycle, gut microbiota metabolism, lipids and cell membranes metabolism, glucose metabolism, fatty acid β-oxidation, amino acids metabolism and ketogenesis. This study assessed and provided important metabolomic variations in serum and urine associated with AR and, therefore, demonstrated metabolomics as a powerful approach for the complete elucidation of the underlying pathophysiologic mechanisms of AR.
Starting Page	1423
Ending Page	1435
Page Count	13
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	9
Issue Number	6
Journal	Molecular BioSystems
DOI	10.1039/c3mb25412g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Spectroscopy Metabolomics Ketogenesis Arthus reaction Liver Nuclear magnetic resonance spectroscopy Inflammation Proton nuclear magnetic resonance Glucose High-performance liquid chromatography Metabolism Beta oxidation Kidney Microbiota TCA Fatty acid Androgen receptor Linear discriminant analysis
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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