NDLI: The pleiotropic effect of WD-40 domain containing proteins on cellular differentiation and production of secondary metabolites in Streptomyces coelicolor

Please wait, while we are loading the content...

Comparative proteome profiling of breast tumor cell lines by gel electrophoresis and mass spectrometry reveals an epithelial mesenchymal transition associated protein signature

Urinary exosomes and diabetic nephropathy: a proteomic approach

Effect of IR laser on myoblasts: a proteomic study

Alteration of proteomic profiles in PBMC isolated from patients with Fabry disease: preliminary findings

Crosstalk between salicylic acid and jasmonate in Arabidopsis investigated by an integrated proteomic and transcriptomic approach

Unravelling the bull fertility proteome

Red blood cell metabolism under prolonged anaerobic storage

Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes

Differential protein profiling of renal cell carcinoma urinary exosomes

Complementary biochemical approaches applied to the identification of plastidial calmodulin-binding proteins

Integrative quantitation enables a comprehensive proteome comparison of two Mycoplasma pneumoniae genetic perturbations

Proteomic analysis of temperature stress-responsive proteins in Arabidopsis thaliana rosette leaves

Network-based drug repositioning

A controllable gene expression system in liposomes that includes a positive feedback loop

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

JAK/STAT signalling – an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology

Homology modeling of dihydrofolate reductase from T. gondii bonded to antagonists: molecular docking and molecular dynamics simulations

Prediction of human genes and diseases targeted by xenobiotics using predictive toxicogenomic-derived models (PTDMs)

A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation

Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins

Large-scale investigation of oxygen response mutants in Saccharomyces cerevisiae

Topological patterns in microRNA–gene regulatory network: studies in colorectal and breast cancer

Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry

A comprehensive analysis of the influence of drug binding kinetics on drug action at molecular and systems levels

Secretome analysis of Glioblastoma cell line - HNGC-2

Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: a new class of peptide amphiphiles

Biomarkers of food intake and metabolite differences between plasma and red blood cell matrices; a human metabolomic profile approach

Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (¹H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC)

Delay-managed tradeoff in the molecular dynamics of the segmentation clock

Computationally identifying virulence factors based on KEGG pathways

The pleiotropic effect of WD-40 domain containing proteins on cellular differentiation and production of secondary metabolites in Streptomyces coelicolor

Molecular dynamic simulations of the tubulin–human gamma synuclein complex: structural insight into the regulatory mechanism involved in inducing resistance against Taxol

Gossypol induces apoptosis in ovarian cancer cells through oxidative stress

A proteomics approach to study the molecular basis of enhanced salt tolerance in barley (Hordeum vulgare L.) conferred by the root mutualistic fungus Piriformospora indica

Discovery of Rho-kinase inhibitors by docking-based virtual screening

Salmonella modulates metabolism during growth under conditions that induce expression of virulence genes

Selective binding of 2′-F-c-di-GMP to Ct-E88 and Cb-E43, new class I riboswitches from Clostridium tetani and Clostridium botulinum respectively

Back cover

Molecular BioSystems Vol - 9 Issue - 5

Molecular BioSystems Vol - 9 Issue - 4

Molecular BioSystems Vol - 9 Issue - 3

Molecular BioSystems Vol - 9 Issue - 2

Molecular BioSystems Vol -8

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

The pleiotropic effect of WD-40 domain containing proteins on cellular differentiation and production of secondary metabolites in Streptomyces coelicolor

Content Provider	Royal Society of Chemistry (RSC)
Author	Branny, Pavel Petříčková, Kateřina Ulrych, Aleš Rampírová, Petra Goldová, Jana Benada, Oldřich Petříček, Miroslav Kofroňová, Olga
Copyright Year	2013
Abstract	The genome of Streptomyces coelicolor encodes six potential WD-40 genes. Two of them, the wdpB (SCO5953) and the wdpC (SCO4422) genes, were studied to determine their function. Deletion of the wdpB gene resulted in a considerable decrease of aerial hyphae formation, leading to a conditionally bald phenotype, and reduced undecylprodigiosin production. In addition, the aerial hyphae of the ΔwdpB mutant strain were unusually branched and showed the signs of irregular septation and precocious lysis. Disruption of wdpC resulted in the reduction of undecylprodigiosin and delayed actinorhodin production. The ΔwdpC mutant strain showed precocious lysis of hyphae and delayed sporulation without typical curling of aerial hyphae in the early sporulation stage. The whole-genome transcriptome analysis revealed that deletion of wdpB affects the expression of genes involved in aerial hyphae differentiation, sporulation and secondary metabolites production. Deletion of wdpC caused downregulation of several gene clusters encoding secondary metabolites. Both the wdp genes seem to possess transcriptional autoregulatory function. Overexpression and genetic complementation studies confirmed the observed phenotype of both mutants. The results obtained suggest that both genes studied have a pleiotropic effect on physiological and morphological differentiation.
Starting Page	1453
Ending Page	1469
Page Count	17
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	9
Issue Number	6
Journal	Molecular BioSystems
DOI	10.1039/c3mb25542e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Phenotype Pleiotropy Gene Lysis Actinorhodin Transcriptome Streptomyces Mutation Genome WD40 repeat
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Disruption of SCO5461 gene coding for a mono-ADP-ribosyltransferase enzyme produces a conditional pleiotropic phenotype affecting morphological differentiation and antibiotic production in Streptomyces coelicolor

Impact of otrA expression on morphological differentiation, actinorhodin production, and resistance to aminoglycosides in Streptomyces coelicolor M145.

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.

Cell immobilization of Streptomyces coelicolor: effect on differentiation and actinorhodin production

Production of actinorhodin by Streptomyces coelicolor A3(2) grown in chemostat culture

ArgR of Streptomyces coelicolor Is a Pleiotropic Transcriptional Regulator: Effect on the Transcriptome, Antibiotic Production, and Differentiation in Liquid Cultures

Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production

Loss of phosphomannomutase activity enhances actinorhodin production in Streptomyces coelicolor

The pleiotropic effect of WD-40 domain containing proteins on cellular differentiation and production of secondary metabolites in Streptomyces coelicolor

Similar Documents

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Disruption of SCO5461 gene coding for a mono-ADP-ribosyltransferase enzyme produces a conditional pleiotropic phenotype affecting morphological differentiation and antibiotic production in Streptomyces coelicolor

Impact of otrA expression on morphological differentiation, actinorhodin production, and resistance to aminoglycosides in Streptomyces coelicolor M145.

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.

Cell immobilization of Streptomyces coelicolor: effect on differentiation and actinorhodin production

Production of actinorhodin by Streptomyces coelicolor A3(2) grown in chemostat culture

ArgR of Streptomyces coelicolor Is a Pleiotropic Transcriptional Regulator: Effect on the Transcriptome, Antibiotic Production, and Differentiation in Liquid Cultures

Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production

Loss of phosphomannomutase activity enhances actinorhodin production in Streptomyces coelicolor

The pleiotropic effect of WD-40 domain containing proteins on cellular differentiation and production of secondary metabolites in Streptomyces coelicolor