NDLI: Neuroprotective effect of loganin against Aβ<sub>25–35</sub>-induced injury <i>via</i> the NF-κB-dependent signaling pathway in PC12 cells

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Food & Function Vol - 6 Issue - 3

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Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Neuroprotective effect of loganin against Aβ_25–35-induced injury via the NF-κB-dependent signaling pathway in PC12 cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Kim, Oh Yoen Jeong, Woo-Sik Ho, Chi-Tang Jun, Mira Kim, Hyeri Ahn, Mok-Ryeon Youn, Kumju
Copyright Year	2015
Abstract	Amyloid-beta (Aβ) protein, the main constituent of senile plaques, is believed to play a pivotal role in the pathogenesis of Alzheimer's disease (AD). AD is closely associated with inflammatory reactions which are considered to be responses to Aβ deposition. The present study investigated the effect of loganin on Aβ25–35-induced inflammatory damage and the underlying molecular mechanism of its neuroprotective action. Loganin predominantly prevented Aβ25–35-stimulated cell death through suppressing ROS generation, and attenuating apoptosis by inhibiting caspase-3 activity and regulating cell cycle. Furthermore, loganin suppressed the level of TNF-α and protein expression of iNOS and COX-2 in Aβ25–35-injured PC12 cells. These inhibitions appeared to correlate with the suppression of NF-κB activation by loganin, as pre-treating cells with loganin blocked the translocation of NF-κB into the nuclear compartment and degradation of the inhibitory subunit IκB. Loganin substantially inhibited phosphorylation of MAPKs including ERK1/2, p38 and JNK, which are closely related to regulation of NF-κB activation. Taken together, the results implied that loganin attenuated neuroinflammatory responses through the inactivation of NF-κB by NF-κB dependent inflammatory pathways and phosphorylation of MAPK in Aβ25–35-induced PC12 cells.
Starting Page	1108
Ending Page	1116
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	4
Journal	Food & Function
DOI	10.1039/c5fo00055f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Amyloid beta Protein Senile plaques Loganin Neuroprotection Reactive oxygen species Apoptosis Cell cycle Tumor necrosis factor alpha Prostaglandin-endoperoxide synthase 2 PC12 cell line NF-κB Phosphorylation MAPK3 P38 mitogen-activated protein kinases C-Jun N-terminal kinases Mitogen-activated protein kinase
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Neuroprotective effect of loganin against Aβ_25–35-induced injury via the NF-κB-dependent signaling pathway in PC12 cells

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