NDLI: Protective effects of alisol B 23-acetate from edible botanical <i>Rhizoma alismatis</i> against carbon tetrachloride-induced hepatotoxicity in mice

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Food & Function Vol - 6 Issue - 3

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Food & Function Vol -1

Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Xinli Wang, Changyuan Liu, Kexin Liu, Zhihao Huo, Xiaokui Meng, Qiang Sun, Pengyuan Liu, Qi Sun, Huijun
Copyright Year	2015
Abstract	Carbon tetrachloride (CCl4)-induced hepatotoxicity is a common syndrome with simultaneous severe hepatocyte death and acute cholestasis. The purpose of the present study is to investigate the hepatoprotective effect of alisol B 23-acetate (AB23A), a natural triterpenoid from edible botanical Rhizoma alismatis, on acute hepatotoxicity induced by CCl4 in mice, and further to elucidate the involvement of farnesoid X receptor (FXR), signal transducers and activators of transcription 3 (STAT3) in the hepatoprotective effect. H&E staining, BrdU immunohistochemistry and TUNEL assay were used to identify the amelioration of histopathological changes, hepatocyte proliferation and apoptosis. Real-time PCR and western blot assay were used to elucidate the mechanisms underlying AB23A hepatoprotection. The results indicated that AB23A treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, AB23A promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. AB23A also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, AB23A induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. In conclusion, AB23A produces a protective effect against CCl4-induced hepatotoxicity, due to FXR and STAT3-mediated gene regulation.
Starting Page	1241
Ending Page	1250
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	4
Journal	Food & Function
DOI	10.1039/c5fo00082c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Carbon tetrachloride Hepatotoxicity Syndrome Hepatocyte Cholestasis Hepatoprotection Triterpene Farnesoid X receptor STAT3 Immunohistochemistry TUNEL assay Apoptosis Polymerase chain reaction Western blot Cyclin D1 Bile Acid Phosphorylation Bcl-xL SOCS3 Gene
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Studies on Alismatis Rhizoma. III. Stereostructures of New Protostane-Type Triterpenes, Alisols H, I, J-23-Acetate, K-23-Acetate, L-23-Acetate, M-23-Acetate, and N-23-Acetate, from the Dried Rhizome of Alisma orientale

Crude Drugs from Aquatic Plants. I. On the Constituents of Alismatis Rhizoma. (1). Absolute Stereostructures of Alisols E 23-Acetate, F, and G, Three New Protostane-Type Triterpenes from Chinese Alismatis Rhizoma

Stability and Structure Studies on Alisol A 24-Acetate

OPTIMIZATION OF EXTRACTION CONDITION FOR ALISOL B AND ALISOL B ACETATE IN ALISMATIS RHIZOMA USING RESPONSE SURFACE METHODOLOGY

ABSOLUTE STEREOSTRUCTURES OF ALISMALACTONE 23-ACETATE AND ALISMAKETONE-A 23-ACETATE, NEW SECO-PROTOSTANE AND PROTOSTANE-TYPE TRITERPENES WITH VASORELAXANT EFFECTS FROM CHINESE ALISMATIS RHIZOMA

Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma

Preparative Isolation of Alisol B and Alisol B 23-Acetate from Alismatis Rhizoma by Centrifugal Partition Chromatography Coupled with ELSD

Optimization of Extraction Condition for Alisol B and Alisol B Acetate in Alismatis Rhizoma using Response Surface Methodology

Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma

Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice

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