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Food & Function Vol - 6 Issue - 3

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A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages

Content Provider	Royal Society of Chemistry (RSC)
Author	Khoo, Christina Kaspar, Kerrie L. Howell, Amy B.
Copyright Year	2015
Abstract	In this study, we examined the ex vivo urinary anti-adhesion activity of low-calorie cranberry extract beverages in both a pilot study (n = 10) and a randomized, double-blind, placebo controlled clinical trial (n = 59). In the pilot study, subjects consumed a cranberry extract beverage (CEB) or a cranberry extract and juice beverage (CEJB), compared to placebo. Both cranberry beverages utilized a standardized cranberry extract powder at a level equivalent to low-calorie cranberry juice cocktail (LCJC) on a PAC content basis. Clean-catch urine samples collected at baseline and post intervention were tested for anti-adhesion activity utilizing a mannose-resistant human red blood cell hemagglutination assay specific for P-fimbriated E. coli. Results from the pilot study indicated that ex vivo anti-adhesion activity for both cranberry treatments were higher (p < 0.05) than placebo. In the clinical trial, we compared CEJB to LCJC and a placebo beverage. Post-consumption urine from both cranberry treatment groups showed significantly higher (p < 0.05) anti-adhesion activity compared to placebo. There were no differences observed in anti-adhesion activity between CJEB and LCJC, indicating similar bioactivity. Therefore, acute beverage consumption of cranberry extract and/or juice provides ex vivo anti-adhesion activity, which may help to improve urinary tract health.
Starting Page	1212
Ending Page	1217
Page Count	6
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	4
Journal	Food & Function
DOI	10.1039/c4fo01018c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	LCJC CJEB Placebo Clinical trial Cranberry juice Cocktail Urine Red blood cell Hemagglutination assay Escherichia coli Urinary system
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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